TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth - Wikidata - wikimedia - TriplyDB

TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth

TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth

http://www.wikidata.org/entity/Q35826016

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Emerging role of Hippo pathway in gastric and other gastrointestinal cancers Cross-talk between Wnt/β-catenin and Hippo signaling pathways: a brief review Cell density sensing alters TGF-β signaling in a cell-type-specific manner, independent from Hippo pathway activation The transcriptional regulators TAZ and YAP direct transforming growth factor β-induced tumorigenic phenotypes in breast cancer cells.Transforming growth factor-beta1 suppresses hepatocellular carcinoma proliferation via activation of Hippo signaling Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation.YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues YAP regulates cell proliferation, migration, and steroidogenesis in adult granulosa cell tumors.Gene expression of mesothelioma in vinylidene chloride-exposed F344/N rats reveal immune dysfunction, tissue damage, and inflammation pathways The emerging roles of YAP and TAZ in cancer Convergent signaling in the regulation of connective tissue growth factor in malignant mesothelioma: TGFβ signaling and defects in the Hippo signaling cascade.A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo.Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis.The role of extracellular biophysical cues in modulating the Hippo-YAP pathway.Smads and cell fate: distinct roles in specification, development, and tumorigenesis in the testis.Molecular pathogenesis of malignant mesothelioma.Functional genomics of the 9p21.3 locus for atherosclerosis: clarity or confusion?ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types Emerging role of Hippo signalling pathway in bladder cancer.Recent advances in understanding contextual TGFβ signaling Targeting YAP in malignant pleural mesothelioma.Fascin 1 promoted the growth and migration of non-small cell lung cancer cells by activating YAP/TEAD signaling.miR-130A as a diagnostic marker to differentiate malignant mesothelioma from lung adenocarcinoma in pleural effusion cytology.YAP/TAZ at the Roots of Cancer.SMAD3 and SP1/SP3 Transcription Factors Collaborate to Regulate Connective Tissue Growth Factor Gene Expression in Myoblasts in Response to Transforming Growth Factor β.Downregulation of VGLL4 in the progression of esophageal squamous cell carcinoma.Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways.LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade.Targeting TGF-β Signaling for Therapeutic Gain.Low Merlin expression and high Survivin labeling index are indicators for poor prognosis in patients with malignant pleural mesothelioma.The GSK3β inhibitor BIS I reverts YAP-dependent EMT signature in PDAC cell lines by decreasing SMADs expression level.YAP signaling in gastric cancer-derived mesenchymal stem cells is critical for its promoting role in cancer progression.Signal integration in TGF-β, WNT, and Hippo pathways Down regulation of lincRNA-p21 contributes to gastric cancer development through Hippo-independent activation of YAP.Connective tissue growth factor and β-catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma.Deregulation of Hippo-TAZ pathway during renal injury confers a fibrotic maladaptive phenotype.Integrin-FAK-CDC42-PP1A signaling gnaws at YAP/TAZ activity to control incisor stem cells.Tissue inhibitor of metalloproteinase-1 promotes cell proliferation through YAP/TAZ activation in cancer.

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P2860

TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth

http://www.wikidata.org/entity/Q35826016

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

TGF-β synergizes with defects ...... malignant mesothelioma growth

@ast

TGF-β synergizes with defects ...... malignant mesothelioma growth

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type

label

TGF-β synergizes with defects ...... malignant mesothelioma growth

@ast

TGF-β synergizes with defects ...... malignant mesothelioma growth

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prefLabel

TGF-β synergizes with defects ...... malignant mesothelioma growth

@ast

TGF-β synergizes with defects ...... malignant mesothelioma growth

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Journal of Experimental Medicine

P1476

TGF-β synergizes with defects ...... malignant mesothelioma growth

@en

P2093

Ayuko Sato

http://www.w3.org/2001/XMLSchema#string

Eisaku Kondo

http://www.w3.org/2001/XMLSchema#string

Hayao Nakanishi

http://www.w3.org/2001/XMLSchema#string

Hideki Murakami

http://www.w3.org/2001/XMLSchema#string

Hidemi Ito

http://www.w3.org/2001/XMLSchema#string

Hirotaka Osada

http://www.w3.org/2001/XMLSchema#string

Makiko Fujii

http://www.w3.org/2001/XMLSchema#string

Takeshi Toyoda

http://www.w3.org/2001/XMLSchema#string

Tohru Tsujimura

http://www.w3.org/2001/XMLSchema#string

Toyoaki Hida

http://www.w3.org/2001/XMLSchema#string

P2860

Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment.

Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways

SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

TEAD mediates YAP-dependent gene induction and growth control

TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm

Matrix crosslinking forces tumor progression by enhancing integrin signaling

Smad transcription factors

TGFbeta in Cancer

Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein

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479-494

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10.1084/JEM.20111653

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3

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209

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221828271

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22329991

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3302232

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