The unique regulation of brain cytochrome P450 2 (CYP2) family enzymes by drugs and genetics.
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Nanotechnology: toxicologic pathologyA mechanistic view of polybrominated diphenyl ether (PBDE) developmental neurotoxicityCytochrome P450-mediated drug metabolism in the brainChronic nicotine treatment induces rat CYP2D in the brain but not in the liver: an investigation of induction and time courseThe Alzheimer pandemic: is paracetamol to blame?Genetic variation in the CYP2B6 gene is related to circulating 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) concentrations: an observational population-based study.Oxidation of the endogenous cannabinoid arachidonoyl ethanolamide by the cytochrome P450 monooxygenases: physiological and pharmacological implications.Predictors of blood trihalomethane concentrations in NHANES 1999-2006.Cytochrome P450 mediates dopamine formation in the brain in vivo.Genetic variability of drug-metabolizing enzymes: the dual impact on psychiatric therapy and regulation of brain function.Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic.Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6.Monocrotophos induces the expression and activity of xenobiotic metabolizing enzymes in pre-sensitized cultured human brain cells.Phase I and Phase II enzyme polymorphisms and childhood cancer.Biotransformation of BDE-47 to potentially toxic metabolites is predominantly mediated by human CYP2B6First demonstration that brain CYP2D-mediated opiate metabolic activation alters analgesia in vivo.Nicotine Increases Codeine Analgesia Through the Induction of Brain CYP2D and Central Activation of Codeine to Morphine.Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment.Methylglyoxal and glucose metabolism: a historical perspective and future avenues for research.ABC transporters and cytochromes P450 in the human central nervous system: influence on brain pharmacokinetics and contribution to neurodegenerative disorders.Blood-brain barrier P450 enzymes and multidrug transporters in drug resistance: a synergistic role in neurological diseases.Genetic polymorphisms of cytochrome P450 enzymes and antidepressant metabolism.Development of individualized medicine for epilepsy based on genetic information.Polymorphism in CYP2D6 and CYP2C19, members of the cytochrome P450 mixed-function oxidase system, in the metabolism of psychotropic drugs.Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs.Consequences of daily corticosteroid dosing with or without pre-treatment with quinidine on the in vivo cytochrome P450 2D (CYP2D) enzyme in rats: effect on O-demethylation activity of dextromethorphan and expression levels of CYP2D1 mRNA.CYP2A6 Genetic Variation Alters Striatal-Cingulate Circuits, Network Hubs, and Executive Processing in Smokers.Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G→T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis.Brain drug-metabolizing cytochrome P450 enzymes are active in vivo, demonstrated by mechanism-based enzyme inhibition.Drug metabolism within the brain changes drug response: selective manipulation of brain CYP2B alters propofol effects.Toxicogenomic analysis of a sustained release local anesthetic delivery system.PharmGKB summary: very important pharmacogene information for CYP2B6.The antiretroviral protease inhibitors indinavir and nelfinavir stimulate Mrp1-mediated GSH export from cultured brain astrocytes.Rat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia.CYP2E1 T7632A and 9-bp insertion polymorphisms and colorectal cancer risk: a meta-analysis based on 4,592 cases and 5,918 controls.Occurrence, distribution and potential actions of CYP2D6 in the brainExtrahepatic Drug-Metabolizing Enzymes and Their Significance
P2860
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P2860
The unique regulation of brain cytochrome P450 2 (CYP2) family enzymes by drugs and genetics.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The unique regulation of brain ...... enzymes by drugs and genetics.
@ast
The unique regulation of brain ...... enzymes by drugs and genetics.
@en
type
label
The unique regulation of brain ...... enzymes by drugs and genetics.
@ast
The unique regulation of brain ...... enzymes by drugs and genetics.
@en
prefLabel
The unique regulation of brain ...... enzymes by drugs and genetics.
@ast
The unique regulation of brain ...... enzymes by drugs and genetics.
@en
P2860
P356
P1476
The unique regulation of brain ...... enzymes by drugs and genetics
@en
P2093
Sharon Miksys
P2860
P304
P356
10.1081/DMR-120034149
P407
P577
2004-05-01T00:00:00Z