Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis.
about
Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalateA reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants.Gene Expression Profiling in Wild-Type and PPARα-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPARα-Independent EffectsDifferential response to trichloroethylene-induced hepatosteatosis in wild-type and PPARalpha-humanized micePPARalpha-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells.Perfluorooctanoic acid (PFOA) acts as a tumor promoter on Syrian hamster embryo (SHE) cells.Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferationThe Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene.The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha.Peroxisome proliferator-activated receptors in lung cancer.Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liverFenofibrate metabolism in the cynomolgus monkey using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics.New metabolites of fenofibrate in Sprague-Dawley rats by UPLC-ESI-QTOF-MS-based metabolomics coupled with LC-MS/MSMode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study.Structure-activity relationships and human relevance for perfluoroalkyl acid-induced transcriptional activation of peroxisome proliferation in liver cell cultures.Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway.PPARs and HCV-Related Hepatocarcinoma: A Mitochondrial Point of View.Decrease of hepatic stellate cells in rats with enhanced sensitivity to clofibrate-induced hepatocarcinogenesis.Di-butyl phthalate-induced hypomethylation of the c-myc gene in rat liver.The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions.Fenofibrate induced PPAR alpha expression was attenuated by oestrogen receptor alpha overexpression in Hep3B cells.Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells.Chronic microcystin exposure induces hepatocyte proliferation with increased expression of mitotic and cyclin-associated genes in P53-deficient mice.
P2860
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P2860
Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Hepatocyte-restricted constitu ...... but not hepatocarcinogenesis.
@ast
Hepatocyte-restricted constitu ...... but not hepatocarcinogenesis.
@en
type
label
Hepatocyte-restricted constitu ...... but not hepatocarcinogenesis.
@ast
Hepatocyte-restricted constitu ...... but not hepatocarcinogenesis.
@en
prefLabel
Hepatocyte-restricted constitu ...... but not hepatocarcinogenesis.
@ast
Hepatocyte-restricted constitu ...... but not hepatocarcinogenesis.
@en
P2093
P2860
P356
P1433
P1476
Hepatocyte-restricted constitu ...... but not hepatocarcinogenesis.
@en
P2093
Frank J Gonzalez
Shinji Ito
P2860
P304
P356
10.1093/CARCIN/BGM046
P407
P577
2007-02-28T00:00:00Z