Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease.
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Oxidative Stress Signaling in Alzheimers DiseaseToward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseSuccessful therapies for Alzheimer's disease: why so many in animal models and none in humans?Some evolutionary perspectives on Alzheimer's disease pathogenesis and pathologyAndrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 miceComputational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-β on synaptic plasticityWhy pleiotropic interventions are needed for Alzheimer's disease.Nanoparticle delivery of transition-metal chelators to the brain: Oxidative stress will never see it coming!Characterization of the interaction of β-amyloid with transthyretin monomers and tetramers.Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's DiseaseThe pathogenesis of Alzheimer's disease: a reevaluation of the "amyloid cascade hypothesis"The Alzheimer structural connectome: changes in cortical network topology with increased amyloid plaque burden.The evolution of preclinical Alzheimer's disease: implications for prevention trials.Role of metal dyshomeostasis in Alzheimer's disease.Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysisAmyloid beta (Aβ) peptide modulators and other current treatment strategies for Alzheimer's disease (AD).Amyloid-beta in Alzheimer's disease: the horse or the cart? Pathogenic or protective?BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer's diseasePre-training Catechin gavage prevents memory impairment induced by intracerebroventricular streptozotocin in ratsAntioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau.Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotypeAre neurodegenerative disorder and psychotic manifestations avoidable brain dysfunctions with adequate dietary omega-3?Regional brain hypometabolism is unrelated to regional amyloid plaque burden.Preclinical Alzheimer disease-the challenges ahead.Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin.Interleukin-1beta: a bridge between inflammation and excitotoxicity?Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease.The butyrylcholinesterase K variant confers structurally derived risks for Alzheimer pathology.Cell number changes in Alzheimer's disease relate to dementia, not to plaques and tangles.The role of iron as a mediator of oxidative stress in Alzheimer disease.Bapineuzumab and solanezumab for Alzheimer's disease: is the 'amyloid cascade hypothesis' still alive?Ligand binding to distinct states diverts aggregation of an amyloid-forming protein.Familial Presenilin Mutations and Sporadic Alzheimer's Disease Pathology: Is the Assumption of Biochemical Equivalence Justified?Rethinking on the concept of biomarkers in preclinical Alzheimer's disease.Emerging biomarkers and screening for cognitive frailty.Computational identification of potential multi-drug combinations for reduction of microglial inflammation in Alzheimer disease.Amyloid-beta vaccination: testing the amyloid hypothesis?: heads we win, tails you lose!Complexing Aβ prevents the cellular anomalies induced by the Peptide alone.Amyloid ion channels: a porous argument or a thin excuse?Down's Syndrome with Alzheimer's Disease-Like Pathology: What Can It Teach Us about the Amyloid Cascade Hypothesis?
P2860
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P2860
Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Challenging the amyloid cascad ...... ptations to Alzheimer disease.
@ast
Challenging the amyloid cascad ...... ptations to Alzheimer disease.
@en
type
label
Challenging the amyloid cascad ...... ptations to Alzheimer disease.
@ast
Challenging the amyloid cascad ...... ptations to Alzheimer disease.
@en
prefLabel
Challenging the amyloid cascad ...... ptations to Alzheimer disease.
@ast
Challenging the amyloid cascad ...... ptations to Alzheimer disease.
@en
P2093
P50
P356
P1476
Challenging the amyloid cascad ...... ptations to Alzheimer disease.
@en
P2093
Atsushi Takeda
Gemma Casadesus
Hyoung-Gon Lee
P356
10.1196/ANNALS.1297.001
P407
P577
2004-06-01T00:00:00Z