Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo - Wikidata - wikimedia - TriplyDB

Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo

Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo

http://www.wikidata.org/entity/Q35836136

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Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease Novel human ABCC9/SUR2 brain-expressed transcripts and an eQTL relevant to hippocampal sclerosis of aging ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target.Aerobic Glycolysis in the Frontal Cortex Correlates with Memory Performance in Wild-Type Mice But Not the APP/PS1 Mouse Model of Cerebral Amyloidosis.Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy.Preserving Cognition in Older African Americans with Mild Cognitive Impairment Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia.Brain aerobic glycolysis and motor adaptation learning.Chronic hyperglycemia induced via the heterozygous knockout of Pdx1 worsens neuropathological lesion in an Alzheimer mouse model Short-Term High-Fat Diet (HFD) Induced Anxiety-Like Behaviors and Cognitive Impairment Are Improved with Treatment by Glyburide.Changes in insulin and insulin signaling in Alzheimer's disease: cause or consequence?High glucose upregulates BACE1-mediated Aβ production through ROS-dependent HIF-1α and LXRα/ABCA1-regulated lipid raft reorganization in SK-N-MC cells.The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old APP/PS1 Mice.T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer's Disease: Potential Pools of New Biomarkers.Glucose directs amyloid-beta into membrane-active oligomers."New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS).HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology.Diabetes, Hemoglobin A1C, and Regional Alzheimer Disease and Infarct Pathology.The diabetic brain and cognition.Impaired fasting glucose is associated with increased regional cerebral amyloid.F1F0 ATP Synthase-Cyclophilin D Interaction Contributes to Diabetes-Induced Synaptic Dysfunction and Cognitive Decline.Central and peripheral circadian clocks and their role in Alzheimer's disease.A high-glycemic diet is associated with cerebral amyloid burden in cognitively normal older adults.Subclinical Doses of ATP-Sensitive Potassium Channel Modulators Prevent Alterations in Memory and Synaptic Plasticity Induced by Amyloid-β.Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model.Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review.Interactions between stress and physical activity on Alzheimer's disease pathology.Alzheimer's Disease and Type 2 Diabetes: A Critical Assessment of the Shared Pathological Traits.Diabetes and Alzheimer's Disease: Mechanisms and Nutritional Aspects

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P2860

Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo

http://www.wikidata.org/entity/Q35836136

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2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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name

Hyperglycemia modulates extrac ...... and neuronal activity in vivo

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Hyperglycemia modulates extrac ...... and neuronal activity in vivo

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Hyperglycemia modulates extrac ...... and neuronal activity in vivo

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P1433

Journal of Clinical Investigation

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Hyperglycemia modulates extrac ...... and neuronal activity in vivo

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Courtney L Sutphen

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David M Holtzman

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Emily E Caesar

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Marcus E Raichle

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Ronaldo Perez

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Steven A Yamada

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P2860

Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease

KATP channels as molecular sensors of cellular metabolism

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization

The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease.

Glucose levels and risk of dementia.

Glucose clamp technique: a method for quantifying insulin secretion and resistance.

Neuronal activity regulates the regional vulnerability to amyloid-β deposition.

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2463-2467

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10.1172/JCI79742

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6

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125

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Thomas E. Mahan

Shannon L Macauley

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2015-05-04T00:00:00Z

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25938784

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4497756

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