about
The Key Role of Calmodulin in KRAS-Driven AdenocarcinomasIntrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pair motionsRas Dimer Formation as a New Signaling Mechanism and Potential Cancer Therapeutic Target.Inhibitors of Ras-SOS Interactions.Seeing is believing: Ras dimers observed in live cellsSpecific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation.The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding RegionsA New View of Ras Isoforms in Cancers.GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding.K-Ras at Anionic Membranes: Orientation, Orientation…Orientation. Recent Simulations and Experiments.Oncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis.The higher level of complexity of K-Ras4B activation at the membrane.Plasma membrane regulates Ras signaling networks.Computational Equilibrium Thermodynamic and Kinetic Analysis of K-Ras Dimerization through an Effector Binding Surface Suggests Limited Functional Role.Inhibition of RAS function through targeting an allosteric regulatory site.Computational and biochemical characterization of two partially overlapping interfaces and multiple weak-affinity K-Ras dimersPrinciples of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation.Deconstruction of the Ras switching cycle through saturation mutagenesis.Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?The renewed battle against RAS-mutant cancers.Applications of isothermal titration calorimetry - the research and technical developments from 2011 to 2015.Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.Membrane orientation dynamics of lipid-modified small GTPases.Intrinsic protein disorder in oncogenic KRAS signaling.Independent and core pathways in oncogenic KRAS signaling.Covalent Ras Dimerization on Membrane Surfaces through Photosensitized Oxidation.Molecular Dynamics Simulations and Dynamic Network Analysis Reveal the Allosteric Unbinding of Monobody to H-Ras Triggered by R135K Mutation.K-Ras4B Remains Monomeric on Membranes over a Wide Range of Surface Densities and Lipid Compositions.Spatiotemporal Analysis of K-Ras Plasma Membrane Interactions Reveals Multiple High Order Homo-oligomeric Complexes.Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output.RAS signaling: Divide and conquer.One-Pot N2C/C2C/N2N Ligation To Trap Weak Protein-Protein Interactions.A "Tug of War" Maintains a Dynamic Protein-Membrane Complex: Molecular Dynamics Simulations of C-Raf RBD-CRD Bound to K-Ras4B at an Anionic Membrane.New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling.Extracellular-Regulated Kinases: Signaling From Ras to ERK Substrates to Control Biological Outcomes.Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain.Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling
P2860
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P2860
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
GTP-Dependent K-Ras Dimerization
@ast
GTP-Dependent K-Ras Dimerization
@en
type
label
GTP-Dependent K-Ras Dimerization
@ast
GTP-Dependent K-Ras Dimerization
@en
prefLabel
GTP-Dependent K-Ras Dimerization
@ast
GTP-Dependent K-Ras Dimerization
@en
P2093
P2860
P1433
P1476
GTP-Dependent K-Ras Dimerization
@en
P2093
Benjamin C Freed
Hyunbum Jang
Karen Stefanisko
Lyuba Khavrutskii
Marzena A Dyba
Nadya I Tarasova
Ozlem Keskin
R Natasha Freed
Ruth Nussinov
Serena Muratcioglu
P2860
P304
P356
10.1016/J.STR.2015.04.019
P577
2015-06-04T00:00:00Z