Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD - Wikidata - wikimedia - TriplyDB

Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

http://www.wikidata.org/entity/Q27697994

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Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin The role of protein dynamics in the evolution of new enzyme function RAS isoforms and mutations in cancer at a glance The RAS-Binding Domain of Human BRAF Protein Serine/Threonine Kinase Exhibits Allosteric Conformational Changes upon Binding HRAS Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration.Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.Mapping the Conformation Space of Wildtype and Mutant H-Ras with a Memetic, Cellular, and Multiscale Evolutionary Algorithm.GTP-Dependent K-Ras Dimerization Inhibitors of Ras-SOS Interactions.Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding A New View of Ras Isoforms in Cancers.GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.KRAS insertion mutations are oncogenic and exhibit distinct functional properties.The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.K-Ras at Anionic Membranes: Orientation, Orientation…Orientation. Recent Simulations and Experiments.Oncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis.Searching for the Chokehold of NRAS Mutant Melanoma.A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling Inhibition of RAS function through targeting an allosteric regulatory site.Deconstruction of the Ras switching cycle through saturation mutagenesis.The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.Molecular Dynamics Simulations Reveal Isoform Specific Contact Dynamics between the Plexin Rho GTPase Binding Domain (RBD) and Small Rho GTPases Rac1 and Rnd1.Molecular and Clinicopathological Differences by Age at the Diagnosis of Colorectal Cancer.Ras: structural details to guide direct targeting.Piconewton-Scale Analysis of Ras-BRaf Signal Transduction with Single-Molecule Force Spectroscopy.Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.Genomic sequencing identifies a few mutations driving the independent origin of primary liver tumors in a chronic hepatitis murine model.Exceptionally high-affinity Ras binders that remodel its effector domain.Protein dynamics: Conformational footprints.The Tiam1 guanine nucleotide exchange factor is auto-inhibited by its pleckstrin homology coiled-coil extension domain.Structural basis for intramolecular interaction of post-translationally modified H-Ras•GTP prepared by protein ligation.Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d.Substrate Recognition of MARTX Ras/Rap1-Specific Endopeptidase.The Protonation States of GTP and GppNHp in Ras Proteins.MYC and RAF: Key Effectors in Cellular Signaling and Major Drivers in Human Cancer.A "Tug of War" Maintains a Dynamic Protein-Membrane Complex: Molecular Dynamics Simulations of C-Raf RBD-CRD Bound to K-Ras4B at an Anionic Membrane.Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain.Phosphorylation promotes binding affinity of Rap-Raf complex by allosteric modulation of switch loop dynamics Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling

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Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

http://www.wikidata.org/entity/Q27697994

description

2015 nî lūn-bûn

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2015 թուականի Մարտին հրատարակուած գիտական յօդուած

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2015 թվականի մարտին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

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Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

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Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

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type

label

Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

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Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

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Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

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prefLabel

Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

@ast

Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

@en

Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

@nl

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J.STR.2014.12.017

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Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

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Bradley M Kearney

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Buyong Ma

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Carla Mattos

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Greg Buhrman

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Hugo Guterres

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Susan K Fetics

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505-16

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scholarly article

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10.1016/J.STR.2014.12.017

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3

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23

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2015-03-03T00:00:00Z

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