Single-molecule force spectroscopy reveals a mechanically stable protein fold and the rational tuning of its mechanical stability.
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Full reconstruction of a vectorial protein folding pathway by atomic force microscopy and molecular dynamics simulations.Nanomechanics of full-length nebulin: an elastic strain gauge in the skeletal muscle sarcomereIdentification of a mechanical rheostat in the hydrophobic core of protein L.Computational and single-molecule force studies of a macro domain protein reveal a key molecular determinant for mechanical stabilityTowards design principles for determining the mechanical stability of proteins.On the improvement of free-energy calculation from steered molecular dynamics simulations using adaptive stochastic perturbation protocols.Revealing the bifurcation in the unfolding pathways of GFP by using single-molecule experiments and simulations.Axis-dependent anisotropy in protein unfolding from integrated nonequilibrium single-molecule experiments, analysis, and simulation.Mechanical biochemistry of proteins one molecule at a time.Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains.Single molecule force spectroscopy reveals engineered metal chelation is a general approach to enhance mechanical stability of proteins.Atomic force microscopy reveals parallel mechanical unfolding pathways of T4 lysozyme: evidence for a kinetic partitioning mechanism.Stabilization provided by neighboring strands is critical for the mechanical stability of proteins.Kinetics of the multistep rupture of fibrin 'A-a' polymerization interactions measured using atomic force microscopyUnderstanding biology by stretching proteins: recent progress.An effective strategy for the design of proteins with enhanced mechanical stability.Non-native interactions are critical for mechanical strength in PKD domains.Multiple Unfolding Intermediates Obtained by Molecular Dynamic Simulations under Stretching for Immunoglobulin-Binding Domain of Protein G.The molecular mechanism underlying mechanical anisotropy of the protein GB1.Recombination of protein fragments: a promising approach toward engineering proteins with novel nanomechanical properties.Enhancing the mechanical stability of proteins through a cocktail approach.Designing cooperativity into the designed protein Top7.Pulling-spring modulation as a method for improving the potential-of-mean-force reconstruction in single-molecule manipulation experiments.The influence of disulfide bonds on the mechanical stability of proteins is context dependent.Mechanical stability analysis of the protein L immunoglobulin-binding domain by full alanine screening using molecular dynamics simulations.Efficient free-energy-profile reconstruction using adaptive stochastic perturbation protocols.Tuning protein mechanics through an ionic cluster graft from an extremophilic protein.Effects of ligand binding on the mechanical stability of protein GB1 studied by steered molecular dynamics simulation.New dynamical window onto the landscape for forced protein unfolding.Criteria for folding in structure-based models of proteins.Injectable dynamic covalent hydrogels of boronic acid polymers cross-linked by bioactive plant-derived polyphenols
P2860
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P2860
Single-molecule force spectroscopy reveals a mechanically stable protein fold and the rational tuning of its mechanical stability.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Single-molecule force spectros ...... g of its mechanical stability.
@ast
Single-molecule force spectros ...... g of its mechanical stability.
@en
type
label
Single-molecule force spectros ...... g of its mechanical stability.
@ast
Single-molecule force spectros ...... g of its mechanical stability.
@en
prefLabel
Single-molecule force spectros ...... g of its mechanical stability.
@ast
Single-molecule force spectros ...... g of its mechanical stability.
@en
P2093
P2860
P50
P356
P1476
Single-molecule force spectros ...... ng of its mechanical stability
@en
P2093
Canaan Lam
Deepak Sharma
P2860
P304
P356
10.1073/PNAS.0700351104
P407
P577
2007-05-21T00:00:00Z