Bispecific designed ankyrin repeat proteins (DARPins) targeting epidermal growth factor receptor inhibit A431 cell proliferation and receptor recycling
about
Applications of Yeast Surface Display for Protein EngineeringDevelopment of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adaptersDesign, construction, and characterization of a second-generation DARPin library with reduced hydrophobicityTuning the drug efflux activity of an ABC transporter in vivo by in vitro selected DARPin bindersA rapid, site-selective and efficient route to the dual modification of DARPins.Methodologies for the isolation of alternative binders with improved clinical potentiality over conventional antibodies.Detection of biomarkers using recombinant antibodies coupled to nanostructured platformsEpitope-guided engineering of monobody binders for in vivo inhibition of Erk-2 signaling.Designed ankyrin repeat proteins: a new approach to mimic complex antigens for diagnostic purposes?Three Recombinant Engineered Antibodies against Recombinant Tags with High Affinity and SpecificityGeneration and Characterization of Rat Monoclonal Antibodies Against Epidermal Growth Factor ReceptorReceptor Crosslinking: A General Method to Trigger Internalization and Lysosomal Targeting of Therapeutic Receptor:Ligand Complexes.A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis.Conformation-dependent recognition of HIV gp120 by designed ankyrin repeat proteins provides access to novel HIV entry inhibitors.Anti-EGFR scFv tetramer (tetrabody) with a stable monodisperse structure, strong anticancer effect, and a long in vivo half-lifeThe Use of Antibodies in Small-Molecule Drug Discovery.Beyond peptides and mAbs--current status and future perspectives for biotherapeutics with novel constructs.Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands.Recent progress in protein-protein interaction study for EGFR-targeted therapeutics.Targeting HER3 using mono- and bispecific antibodies or alternative scaffolds.Multimerization of anti-(epidermal growth factor receptor) IgG fragments induces an antitumor effect: the case for humanized 528 scFv multimers.Novel biotechnology approaches in colorectal cancer diagnosis and therapy.Protein design of IgG/TCR chimeras for the co-expression of Fab-like moieties within bispecific antibodies.Boehmenan, a Lignan From the Chinese Medicinal Plant Clematis armandii, Inhibits A431 Cell Growth via Blocking p70S6/S6 Kinase Pathway.Novel RANKL DE-loop mutants antagonize RANK-mediated osteoclastogenesis.A Conjugate of an Anti-Epidermal Growth Factor Receptor (EGFR) VHH and a Cell-Penetrating Peptide Drives Receptor Internalization and Blocks EGFR Activation.
P2860
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P2860
Bispecific designed ankyrin repeat proteins (DARPins) targeting epidermal growth factor receptor inhibit A431 cell proliferation and receptor recycling
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Bispecific designed ankyrin re ...... eration and receptor recycling
@ast
Bispecific designed ankyrin re ...... eration and receptor recycling
@en
type
label
Bispecific designed ankyrin re ...... eration and receptor recycling
@ast
Bispecific designed ankyrin re ...... eration and receptor recycling
@en
prefLabel
Bispecific designed ankyrin re ...... eration and receptor recycling
@ast
Bispecific designed ankyrin re ...... eration and receptor recycling
@en
P2093
P2860
P356
P1476
Bispecific designed ankyrin re ...... eration and receptor recycling
@en
P2093
Daniel Steiner
Ginger Chao
K Dane Wittrup
Ykelien L Boersma
P2860
P304
41273-41285
P356
10.1074/JBC.M111.293266
P407
P577
2011-10-06T00:00:00Z