Mutational analysis of the beta-type platelet-derived growth factor receptor defines the site of interaction with the bovine papillomavirus type 1 E5 transforming protein.
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The Canine Papillomavirus E5 Protein Signals from the Endoplasmic ReticulumArtificial transmembrane oncoproteins smaller than the bovine papillomavirus E5 protein redefine sequence requirements for activation of the platelet-derived growth factor beta receptor.Bovine papillomavirus E5 protein induces oligomerization and trans-phosphorylation of the platelet-derived growth factor beta receptor.The bovine papillomavirus E5 protein requires a juxtamembrane negative charge for activation of the platelet-derived growth factor beta receptor and transformation of C127 cells.The E5 proteinsViral miniproteinsPapillomavirus E5: the smallest oncoprotein with many functions.E5 oncoprotein transmembrane mutants dissociate fibroblast transforming activity from 16-kilodalton protein binding and platelet-derived growth factor receptor binding and phosphorylation.Identification of amino acids in the transmembrane and juxtamembrane domains of the platelet-derived growth factor receptor required for productive interaction with the bovine papillomavirus E5 protein.Hydrophobic Mismatch Drives the Interaction of E5 with the Transmembrane Segment of PDGF Receptor.The Function of V-ATPases in CancerA single amino acid substitution converts a transmembrane protein activator of the platelet-derived growth factor β receptor into an inhibitor.The bovine papillomavirus E5 protein and the PDGF beta receptor: it takes two to tango.Compensatory mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor β receptor reveal a complex direct transmembrane interaction.Role of glutamine 17 of the bovine papillomavirus E5 protein in platelet-derived growth factor beta receptor activation and cell transformation.Human immunodeficiency virus infection of T-lymphoblastoid cells reduces intracellular pH.Productive interaction between transmembrane mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor beta receptor.Two transmembrane dimers of the bovine papillomavirus E5 oncoprotein clamp the PDGF β receptor in an active dimeric conformation.
P2860
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P2860
Mutational analysis of the beta-type platelet-derived growth factor receptor defines the site of interaction with the bovine papillomavirus type 1 E5 transforming protein.
description
1995 nî lūn-bûn
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1995年の論文
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1995年論文
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1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
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1995年论文
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1995年论文
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1995年论文
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name
Mutational analysis of the bet ...... ype 1 E5 transforming protein.
@ast
Mutational analysis of the bet ...... ype 1 E5 transforming protein.
@en
type
label
Mutational analysis of the bet ...... ype 1 E5 transforming protein.
@ast
Mutational analysis of the bet ...... ype 1 E5 transforming protein.
@en
prefLabel
Mutational analysis of the bet ...... ype 1 E5 transforming protein.
@ast
Mutational analysis of the bet ...... ype 1 E5 transforming protein.
@en
P2093
P2860
P1433
P1476
Mutational analysis of the bet ...... type 1 E5 transforming protein
@en
P2093
A Staebler
D J Goldstein
J H Pierce
M A Heidaran
R Schlegel
S Brazinski
P2860
P304
P407
P577
1995-10-01T00:00:00Z