Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity.
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Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicityGene therapy for mucopolysaccharidosisHematopoietic stem cell gene therapy:assessing the relevance of preclinical modelsHematopoietic stem cell engineering at a crossroadsGene therapy on the moveIs genetic rescue of cystinosis an achievable treatment goal?Identifying Cancer Driver Genes Using Replication-Incompetent Retroviral VectorsCharting a clear path: the ASGCT Standardized Pathways ConferenceRetroviral integration process in the human genome: is it really non-random? A new statistical approach.The 3' region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity.Concise review: lessons learned from clinical trials of gene therapy in monogenic immunodeficiency diseases.β-globin gene transfer to human bone marrow for sickle cell disease.Rescue of pyruvate kinase deficiency in mice by gene therapy using the human isoenzymeCell- and gene-based therapeutic approaches for neurological deficits in mucopolysaccharidosesStem cell marking with promotor-deprived self-inactivating retroviral vectors does not lead to induced clonal imbalance.Self-inactivating retroviral vector-mediated gene transfer induces oncogene activation and immortalization of primary murine bone marrow cells.Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.Genotoxic potential of lineage-specific lentivirus vectors carrying the beta-globin locus control region.Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator.Sleeping beauty transposition from nonintegrating lentivirus.Mechanism of reduction in titers from lentivirus vectors carrying large inserts in the 3'LTR.Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis.Neonatal intravenous injection of a gammaretroviral vector has a low incidence of tumor induction in mice.Decitabine suspends human CD34+ cell differentiation and proliferation during lentiviral transduction.A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells.Use of the piggyBac transposon to create stable packaging cell lines for the production of clinical-grade self-inactivating γ-retroviral vectors.Repetitive busulfan administration after hematopoietic stem cell gene therapy associated with a dominant HDAC7 clone in a nonhuman primate.Gene therapy strategies: can we eradicate HIV?Scale-up and manufacturing of clinical-grade self-inactivating γ-retroviral vectors by transient transfectionEx vivo expansion of retrovirally transduced primate CD34+ cells results in overrepresentation of clones with MDS1/EVI1 insertion sites in the myeloid lineage after transplantation.Gammaretroviral vectors: biology, technology and applicationPreclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of β-thalassemia and sickle cell disease.In vivo biosafety model to assess the risk of adverse events from retroviral and lentiviral vectors.Deletion of the LTR enhancer/promoter has no impact on the integration profile of MLV vectors in human hematopoietic progenitors.Tracking of specific integrant clones in dogs treated with foamy virus vectors.Knockdown of HPRT for selection of genetically modified human hematopoietic progenitor cellsMouse transplant models for evaluating the oncogenic risk of a self-inactivating XSCID lentiviral vectorHighly efficient large-scale lentiviral vector concentration by tandem tangential flow filtration.Treatment of canine leukocyte adhesion deficiency by foamy virus vectors expressing CD18 from a PGK promoter.Contributions of gene marking to cell and gene therapies.
P2860
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P2860
Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Cell-culture assays reveal the ...... for insertional genotoxicity.
@ast
Cell-culture assays reveal the ...... for insertional genotoxicity.
@en
type
label
Cell-culture assays reveal the ...... for insertional genotoxicity.
@ast
Cell-culture assays reveal the ...... for insertional genotoxicity.
@en
prefLabel
Cell-culture assays reveal the ...... for insertional genotoxicity.
@ast
Cell-culture assays reveal the ...... for insertional genotoxicity.
@en
P2093
P2860
P1433
P1476
Cell-culture assays reveal the ...... for insertional genotoxicity.
@en
P2093
Christopher Baum
Jens Bohne
Manfred Schmidt
Sabine Knöss
Ute Modlich
P2860
P304
P356
10.1182/BLOOD-2005-08-024976
P407
P577
2006-07-06T00:00:00Z