about
Highly significant antiviral activity of HIV-1 LTR-specific tre-recombinase in humanized miceLEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropeniaGlycomic Characterization of Induced Pluripotent Stem Cells Derived from a Patient Suffering from Phosphomannomutase 2 Congenital Disorder of Glycosylation (PMM2-CDG)Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesisAdvantages and applications of CAR-expressing natural killer cellsMultiplexing RMCE: versatile extensions of the Flp-recombinase-mediated cassette-exchange technologyGeneration of healthy mice from gene-corrected disease-specific induced pluripotent stem cellsA differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damageImproved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickaseA self-inactivating gamma-retroviral vector reduces manifestations of mucopolysaccharidosis I in miceLentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia.Gene therapy for Wiskott-Aldrich syndrome--long-term efficacy and genotoxicity.Novel self-inactivating vectors for reconstitution of Wiskott-Aldrich syndrome.Generation of HLA-universal iPSCs-derived megakaryocytes and platelets for survival under refractoriness conditions.Modified lentiviral LTRs allow Flp recombinase-mediated cassette exchange and in vivo tracing of "factor-free" induced pluripotent stem cells.Stem cell marking with promotor-deprived self-inactivating retroviral vectors does not lead to induced clonal imbalance.Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34+ Cells for Correction of Fabry DiseaseA suicide gene approach using the human pro-apoptotic protein tBid inhibits HIV-1 replicationProtein transduction from retroviral Gag precursorsmiRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2.Minicircle performance depending on S/MAR-nuclear matrix interactions.Skin tissue generation by laser cell printing.Comparison of the activity and pluripotency maintaining potential of human leukemia inhibitory factor (LIF) produced in E.coli and CHO cells.Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.Gammaretroviral vectors: biology, technology and applicationGene therapy: X-SCID transgene leukaemogenicity.MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML.A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.Induction of pluripotent stem cells from a cynomolgus monkey using a polycistronic simian immunodeficiency virus-based vector, differentiation toward functional cardiomyocytes, and generation of stably expressing reporter lines.Avoiding cytotoxicity of transposases by dose-controlled mRNA deliveryFAS-based cell depletion facilitates the selective isolation of mouse induced pluripotent stem cellsCorrection of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning.Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity.The phenotype of human STK4 deficiency.Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress.Overcoming reprogramming resistance of Fanconi anemia cells.Vector design for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells.Inhibition of miRNA-212/132 improves the reprogramming of fibroblasts into induced pluripotent stem cells by de-repressing important epigenetic remodelling factors.
P50
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P50
description
onderzoeker
@nl
name
Axel Schambach
@ast
Axel Schambach
@en
Axel Schambach
@es
Axel Schambach
@nl
Axel Schambach
@sl
type
label
Axel Schambach
@ast
Axel Schambach
@en
Axel Schambach
@es
Axel Schambach
@nl
Axel Schambach
@sl
prefLabel
Axel Schambach
@ast
Axel Schambach
@en
Axel Schambach
@es
Axel Schambach
@nl
Axel Schambach
@sl