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Function, regulation and pathological roles of the Gab/DOS docking proteinsPhosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking proteinGAB2--a scaffolding protein in cancerStructure and function of Gab2 and its role in cancer (Review)Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategiesGab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell functionA self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells.The different functions of Stat5 and chromatin alteration through Stat5 proteinsA germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lungInterleukin-3 (IL-3)-induced c-fos activation is modulated by Gab2-calcineurin interaction.Gab2 promotes colony-stimulating factor 1-regulated macrophage expansion via alternate effectors at different stages of development.Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production.Gab1 mediates hepatocyte growth factor-stimulated mitogenicity and morphogenesis in multipotent myeloid cells.Changes in Gab2 phosphorylation and interaction partners in response to interleukin (IL)-2 stimulation in T-lymphocytes.Functional screen identifies regulators of murine hematopoietic stem cell repopulationDistinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.Docking proteins.Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycinGab adapter proteins as therapeutic targets for hematologic disease.Stat5 Exerts Distinct, Vital Functions in the Cytoplasm and Nucleus of Bcr-Abl+ K562 and Jak2(V617F)+ HEL Leukemia Cells.Gab docking proteins in cardiovascular disease, cancer, and inflammation.Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Abnormal hematopoiesis in Gab2 mutant mice
@ast
Abnormal hematopoiesis in Gab2 mutant mice
@en
type
label
Abnormal hematopoiesis in Gab2 mutant mice
@ast
Abnormal hematopoiesis in Gab2 mutant mice
@en
prefLabel
Abnormal hematopoiesis in Gab2 mutant mice
@ast
Abnormal hematopoiesis in Gab2 mutant mice
@en
P2093
P2860
P1433
P1476
Abnormal hematopoiesis in Gab2 mutant mice
@en
P2093
Cheng-Kui Qu
Eleonora Haviernikova
Ernesto Diaz-Flores
Geqiang Li
Kevin D Bunting
Kevin M Shannon
William Tse
Zhengqi Wang
P2860
P304
P356
10.1182/BLOOD-2006-11-060707
P407
P577
2007-03-20T00:00:00Z