HIV and SIV CTL escape: implications for vaccine design.
about
Design and pre-clinical evaluation of a universal HIV-1 vaccineVariable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) responseAnimal Models for HIV Cure ResearchMechanisms of HIV protein degradation into epitopes: implications for vaccine designInvestigating CTL mediated killing with a 3D cellular automatonViral CTL escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute SIV infection of macaquesPrevention of Cytotoxic T Cell Escape Using a Heteroclitic Subdominant Viral T Cell DeterminantAnnulling a dangerous liaison: vaccination strategies against AIDS and tuberculosisMultiplex RT-PCR amplification of HIV genes to create a completely autologous DC-based immunotherapy for the treatment of HIV infectionHLA-driven convergence of HIV-1 viral subtypes B and F toward the adaptation to immune responses in human populationsWithin-host stochastic emergence dynamics of immune-escape mutantsTiming of CD8 T cell effector responses in viral infectionsMHC signaling during social communicationEvolutionary dynamics of HIV at multiple spatial and temporal scales.Human immunodeficiency virus vaccine trialsSpin models inferred from patient-derived viral sequence data faithfully describe HIV fitness landscapesFully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection.CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitopeGoing wild: lessons from naturally occurring T-lymphotropic lentivirusesEstimating Costs and Benefits of CTL Escape Mutations in SIV/HIV Infection.Synonymous substitution rates predict HIV disease progression as a result of underlying replication dynamicsPost-infection immunodeficiency virus control by neutralizing antibodiesMolecular evolution of human immunodeficiency virus type 1 upon transmission between human leukocyte antigen disparate donor-recipient pairs.Dynamics of immune escape during HIV/SIV infection.Genomic plasticity of the immune-related Mhc class I B region in macaque species.Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.Frequent toggling between alternative amino acids is driven by selection in HIV-1HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins.Trafficking, persistence, and activation state of adoptively transferred allogeneic and autologous Simian Immunodeficiency Virus-specific CD8(+) T cell clones during acute and chronic infection of rhesus macaquesHLA-associated immune pressure on Gag protein in CRF01_AE-infected individuals and its association with plasma viral load.CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells.Similar impact of CD8+ T cell responses on early virus dynamics during SIV infections of rhesus macaques and sooty mangabeys.The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design.Signature for long-term vaccine-mediated control of a Simian and human immunodeficiency virus 89.6P challenge: stable low-breadth and low-frequency T-cell response capable of coproducing gamma interferon and interleukin-2.Vaccination with Gag, Vif, and Nef gene fragments affords partial control of viral replication after mucosal challenge with SIVmac239Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infectionConstrained pattern of viral evolution in acute and early HCV infection limits viral plasticity.The role of recombination for the coevolutionary dynamics of HIV and the immune responseT-cell immune responses against Env from CRF12_BF and subtype B HIV-1 show high clade-specificity that can be overridden by multiclade immunizationsIncreased immunogenicity of HIV-1 p24 and gp120 following immunization with gp120/p24 fusion protein vaccine expressing alpha-gal epitopes
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P2860
HIV and SIV CTL escape: implications for vaccine design.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
HIV and SIV CTL escape: implications for vaccine design.
@ast
HIV and SIV CTL escape: implications for vaccine design.
@en
type
label
HIV and SIV CTL escape: implications for vaccine design.
@ast
HIV and SIV CTL escape: implications for vaccine design.
@en
prefLabel
HIV and SIV CTL escape: implications for vaccine design.
@ast
HIV and SIV CTL escape: implications for vaccine design.
@en
P2860
P356
P1476
HIV and SIV CTL escape: implications for vaccine design.
@en
P2093
Philip J R Goulder
P2860
P304
P356
10.1038/NRI1417
P577
2004-08-01T00:00:00Z