Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage.
about
Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complexThe complete nucleotide sequence of the human immunoglobulin heavy chain variable region locusStructure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsisDeterminants for hairpin formation in Tn10 transposition.Sequence features of HLA-DRB1 locus define putative basis for gene conversion and point mutationsHMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex.Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences.Functional analysis of coordinated cleavage in V(D)J recombination.Differential requirements for cis and trans V(D)J cleavage: effects of substrate lengthNon-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.Initiation of V(D)J recombination in vivo: role of recombination signal sequences in formation of single and paired double-strand breaks.Stimulation of V(D)J cleavage by high mobility group proteins.Transposase makes critical contacts with, and is stimulated by, single-stranded DNA at the P element termini in vitro.Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly.Synapsis alters RAG-mediated nicking at Tcrb recombination signal sequences: implications for the “beyond 12/23” ruleDetection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking.Postcleavage sequence specificity in V(D)J recombination.Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficienciesConditional RAG-1 mutants block the hairpin formation step of V(D)J recombination.A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.High-resolution description of antibody heavy-chain repertoires in humans.The RAG proteins in V(D)J recombination: more than just a nuclease.Targeted transposition by the V(D)J recombinase.Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinaseInverse transposition by the RAG1 and RAG2 proteins: role reversal of donor and target DNA.V(D)J recombination frequency is affected by the sequence interposed between a pair of recombination signals: sequence comparison reveals a putative recombinational enhancer element.Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage.Base flipping in V(D)J recombination: insights into the mechanism of hairpin formation, the 12/23 rule, and the coordination of double-strand breaksDrosophila P-element transposase is a novel site-specific endonuclease.Patterns of sequence conservation at termini of long terminal repeat (LTR) retrotransposons and DNA transposons in the human genome: lessons from phage Mu.Requirements for DNA hairpin formation by RAG1/2DNA cleavage activity of the V(D)J recombination protein RAG1 is autoregulated.V(H) replacement in rearranged immunoglobulin genes.Recruitment of RAG1 and RAG2 to Chromatinized DNA during V(D)J Recombination.Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells.Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia.DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequencesCryptic signals and the fidelity of V(D)J joining.A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity.V(D)J recombination: in vitro coding joint formation.
P2860
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P2860
Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Distinct DNA sequence and stru ...... recombination signal cleavage.
@ast
Distinct DNA sequence and stru ...... recombination signal cleavage.
@en
type
label
Distinct DNA sequence and stru ...... recombination signal cleavage.
@ast
Distinct DNA sequence and stru ...... recombination signal cleavage.
@en
prefLabel
Distinct DNA sequence and stru ...... recombination signal cleavage.
@ast
Distinct DNA sequence and stru ...... recombination signal cleavage.
@en
P2093
P2860
P1433
P1476
Distinct DNA sequence and stru ...... recombination signal cleavage.
@en
P2093
D A Ramsden
D C van Gent
J F McBlane
P2860
P304
P407
P577
1996-06-01T00:00:00Z