Initiation of V(D)J recombination in vivo: role of recombination signal sequences in formation of single and paired double-strand breaks.
about
A functional analysis of the spacer of V(D)J recombination signal sequencesTarget DNA structure plays a critical role in RAG transposition.Differential requirements for cis and trans V(D)J cleavage: effects of substrate lengthNon-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends.Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking.A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination.Conditional RAG-1 mutants block the hairpin formation step of V(D)J recombination.Ordered assembly of the V(D)J synaptic complex ensures accurate recombinationWhat prevents intermolecular V(D)J recombination?The RAG proteins in V(D)J recombination: more than just a nuclease.Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinaseBase flipping in V(D)J recombination: insights into the mechanism of hairpin formation, the 12/23 rule, and the coordination of double-strand breaksKu80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferaseDrosophila P-element transposase is a novel site-specific endonuclease.Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining.Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination.Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine modelImpaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.The T cell receptor beta enhancer promotes access and pairing of Dbeta and Jbeta gene segments during V(D)J recombinationThe RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation stepV(D)J recombination intermediates and non-standard products in XRCC4-deficient cells.Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination.The effect of Me2+ cofactors at the initial stages of V(D)J recombination.H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations.Amino acid residues in Rag1 crucial for DNA hairpin formation.Developmental regulation of V(D)J recombination at the TCR alpha/delta locus.
P2860
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P2860
Initiation of V(D)J recombination in vivo: role of recombination signal sequences in formation of single and paired double-strand breaks.
description
1997 nî lūn-bûn
@nan
1997 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
Initiation of V(D)J recombinat ...... d paired double-strand breaks.
@ast
Initiation of V(D)J recombinat ...... d paired double-strand breaks.
@en
type
label
Initiation of V(D)J recombinat ...... d paired double-strand breaks.
@ast
Initiation of V(D)J recombinat ...... d paired double-strand breaks.
@en
prefLabel
Initiation of V(D)J recombinat ...... d paired double-strand breaks.
@ast
Initiation of V(D)J recombinat ...... d paired double-strand breaks.
@en
P2093
P2860
P356
P1433
P1476
Initiation of V(D)J recombinat ...... d paired double-strand breaks.
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/16.10.2656
P407
P577
1997-05-01T00:00:00Z