Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD - Wikidata - wikimedia - TriplyDB

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

http://www.wikidata.org/entity/Q35852752

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Regulation of signaling events involved in the pathophysiology of neovascular AMD Inflammation and its role in age-related macular degeneration Parainflammation, chronic inflammation, and age-related macular degeneration The Evolving Functions of Autophagy in Ocular Health: A Double-edged Sword Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells.Mitochondrial expression and activity of P-glycoprotein under oxidative stress in outer blood-retinal barrier Investigating mitochondria as a target for treating age-related macular degeneration A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in mice Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice CETP/LPL/LIPC gene polymorphisms and susceptibility to age-related macular degeneration.Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy.Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration Unfolded protein response is activated in aged retinas.Lysosomes: Regulators of autophagy in the retinal pigmented epithelium.RAGE mediated intracellular Aβ uptake contributes to the breakdown of tight junction in retinal pigment epithelium.Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration.Mitochondrial elongation in the macular RPE of aging monkeys, evidence of metabolic stress.Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo.Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration.Dysregulated autophagy increased melanocyte sensitivity to H2O2-induced oxidative stress in vitiligo.Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration.Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage.Continuous exposure to non-lethal doses of sodium iodate induces retinal pigment epithelial cell dysfunction.Mitochondrial DNA has a pro-inflammatory role in AMD.The cellular autophagy/apoptosis checkpoint during inflammation.Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD.The role and therapeutic potential of melatonin in age-related ocular diseases.Pharmacological Modulation of Photoreceptor Outer Segment Degradation in a Human iPS Cell Model of Inherited Macular Degeneration.Autophagy Proteins ATG5 and ATG7 Are Essential for the Maintenance of Human CD34(+) Hematopoietic Stem-Progenitor Cells.Cigarette smoke induced autophagy-impairment regulates AMD pathogenesis mechanisms in ARPE-19 cells.Ex-vivo models of the Retinal Pigment Epithelium (RPE) in long-term culture faithfully recapitulate key structural and physiological features of native RPE.Depletion of the Third Complement Component Ameliorates Age-Dependent Oxidative Stress and Positively Modulates Autophagic Activity in Aged Retinas in a Mouse Model The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs.Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development.Adeno-Associated Viral Vector-Mediated mTOR Inhibition by Short Hairpin RNA Suppresses Laser-Induced Choroidal Neovascularization.

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Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

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Dysregulated autophagy in the ...... ty to oxidative stress and AMD

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Dysregulated autophagy in the ...... ty to oxidative stress and AMD

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Alfred Lewin

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Catherine Bowes Rickman

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Chunjuan Song

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Debra Akin

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Haoyu Mao

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Haripriya Rao

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Jindong Ding

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Maria Grant

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Michael Boulton

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Sayak K Mitter

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Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2

Autophagy and disease: always two sides to a problem

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

Review: autophagy in neurodegeneration: firefighter and/or incendiarist?

The role of autophagy in age-related neurodegeneration

The 5HT1a receptor agonist 8-Oh DPAT induces protection from lipofuscin accumulation and oxidative stress in the retinal pigment epithelium

Studies on the mechanisms of autophagy: formation of the autophagic vacuole

Autophagy regulates lipid metabolism

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