Human adenovirus type 9 E4 open reading frame 1 encodes a cytoplasmic transforming protein capable of increasing the oncogenicity of CREF cells
about
Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor proteinMulti-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteinsLink of the unique oncogenic properties of adenovirus type 9 E4-ORF1 to a select interaction with the candidate tumor suppressor protein ZO-2Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteinsThe human adenovirus E4-ORF1 protein subverts discs large 1 to mediate membrane recruitment and dysregulation of phosphatidylinositol 3-kinaseOncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressorComputational analysis and identification of an emergent human adenovirus pathogen implicated in a respiratory fatality.Transforming potential of the adenovirus type 5 E4orf3 protein.Induction of transformation and p53-dependent apoptosis by adenovirus type 5 E4orf6/7 cDNA.Several E4 region functions influence mammary tumorigenesis by human adenovirus type 9Hijacking Dlg1 for oncogenic phosphatidylinositol 3-kinase activation in human epithelial cells is a conserved mechanism of human adenovirus E4-ORF1 proteins.A new crucial protein interaction element that targets the adenovirus E4-ORF1 oncoprotein to membrane vesiclesHuman adenovirus early region 4 open reading frame 1 genes encode growth-transforming proteins that may be distantly related to dUTP pyrophosphatase enzymes.Mutant adenovirus type 9 E4 ORF1 genes define three protein regions required for transformation of CREF cells.A carboxy-terminal region required by the adenovirus type 9 E4 ORF1 oncoprotein for transformation mediates direct binding to cellular polypeptides.Viral oncoprotein-induced mislocalization of select PDZ proteins disrupts tight junctions and causes polarity defects in epithelial cells.Discs-Large and Strabismus are functionally linked to plasma membrane formation.Cell polarity proteins: common targets for tumorigenic human viruses.Selective PDZ protein-dependent stimulation of phosphatidylinositol 3-kinase by the adenovirus E4-ORF1 oncoprotein.Two distinct activities contribute to the oncogenic potential of the adenovirus type 5 E4orf6 protein.Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo.
P2860
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P2860
Human adenovirus type 9 E4 open reading frame 1 encodes a cytoplasmic transforming protein capable of increasing the oncogenicity of CREF cells
description
1996 nî lūn-bûn
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1996年の論文
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1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
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1996年论文
@zh-cn
name
Human adenovirus type 9 E4 ope ...... the oncogenicity of CREF cells
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Human adenovirus type 9 E4 ope ...... the oncogenicity of CREF cells
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type
label
Human adenovirus type 9 E4 ope ...... the oncogenicity of CREF cells
@ast
Human adenovirus type 9 E4 ope ...... the oncogenicity of CREF cells
@en
prefLabel
Human adenovirus type 9 E4 ope ...... the oncogenicity of CREF cells
@ast
Human adenovirus type 9 E4 ope ...... the oncogenicity of CREF cells
@en
P2093
P2860
P1433
P1476
Human adenovirus type 9 E4 ope ...... the oncogenicity of CREF cells
@en
P2093
M J McArthur
R T Javier
P2860
P304
P407
P577
1996-02-01T00:00:00Z