Characterization of a DNA binding domain in the C-terminus of HIV-1 integrase by deletion mutagenesis
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Acetylation of HIV-1 integrase by p300 regulates viral integration.Posttranslational acetylation of the human immunodeficiency virus type 1 integrase carboxyl-terminal domain is dispensable for viral replicationStructure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein.Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase.Dissecting the role of the N-terminal domain of human immunodeficiency virus integrase by trans-complementation analysisA novel small molecular weight compound with a carbazole structure that demonstrates potent human immunodeficiency virus type-1 integrase inhibitory activity.Monoclonal antibodies against the minimal DNA-binding domain in the carboxyl-terminal region of human immunodeficiency virus type 1 integrase.Mapping viral DNA specificity to the central region of integrase by using functional human immunodeficiency virus type 1/visna virus chimeric proteinsEfficient gap repair catalyzed in vitro by an intrinsic DNA polymerase activity of human immunodeficiency virus type 1 integrase.A chimeric Ty3/Moloney murine leukemia virus integrase protein is active in vivo.Mutations in the human immunodeficiency virus type 1 integrase D,D(35)E motif do not eliminate provirus formation.Integrase-lexA fusion proteins incorporated into human immunodeficiency virus type 1 that contains a catalytically inactive integrase gene are functional to mediate integrationCritical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking.A large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration.Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction.Structural properties of HIV integrase. Lens epithelium-derived growth factor oligomers.Developing G-quartet oligonucleotides as novel anti-HIV agents: focus on anti-HIV drug design.Molecular dynamics studies on the HIV-1 integrase catalytic domain.Comparison of multiple molecular dynamics trajectories calculated for the drug-resistant HIV-1 integrase T66I/M154I catalytic domain.Allosteric inhibitor development targeting HIV-1 integrase.Expression and partial purification of enzymatically active recombinant Ty1 integrase in Saccharomyces cerevisiaeHIV-2 integrase polymorphisms and longitudinal genotypic analysis of HIV-2 infected patients failing a raltegravir-containing regimen.Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription.Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sitesMultiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replicationMonoclonal antibodies against Rous sarcoma virus integrase protein exert differential effects on integrase function in vitroMapping domains of retroviral integrase responsible for viral DNA specificity and target site selection by analysis of chimeras between human immunodeficiency virus type 1 and visna virus integrases.Sequences in the human immunodeficiency virus type 1 U3 region required for in vivo and in vitro integration.Monoclonal antibodies against human immunodeficiency virus type 1 integrase: epitope mapping and differential effects on integrase activities in vitroCoordinated disintegration reactions mediated by Moloney murine leukemia virus integrase.Inhibition of human immunodeficiency virus type 1 integrase by the Fab fragment of a specific monoclonal antibody suggests that different multimerization states are required for different enzymatic functions.Functional domains of Moloney murine leukemia virus integrase defined by mutation and complementation analysisZinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activityGenetic analysis of the human immunodeficiency virus type 1 integrase protein.The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding.The GP(Y/F) domain of TF1 integrase multimerizes when present in a fragment, and substitutions in this domain reduce enzymatic activity of the full-length protein.Structural biology of retroviral DNA integration.Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding.Role of the nonspecific DNA-binding region and alpha helices within the core domain of retroviral integrase in selecting target DNA sites for integration.Characterization of the human spuma retrovirus integrase by site-directed mutagenesis, by complementation analysis, and by swapping the zinc finger domain of HIV-1.
P2860
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P2860
Characterization of a DNA binding domain in the C-terminus of HIV-1 integrase by deletion mutagenesis
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Characterization of a DNA bind ...... egrase by deletion mutagenesis
@ast
Characterization of a DNA bind ...... egrase by deletion mutagenesis
@en
type
label
Characterization of a DNA bind ...... egrase by deletion mutagenesis
@ast
Characterization of a DNA bind ...... egrase by deletion mutagenesis
@en
prefLabel
Characterization of a DNA bind ...... egrase by deletion mutagenesis
@ast
Characterization of a DNA bind ...... egrase by deletion mutagenesis
@en
P2860
P356
P1476
Characterization of a DNA bind ...... egrase by deletion mutagenesis
@en
P2093
Marcus-Sekura CJ
Woerner AM
P2860
P304
P356
10.1093/NAR/21.15.3507
P407
P577
1993-07-01T00:00:00Z