Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. - Wikidata - wikimedia - TriplyDB

Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

http://www.wikidata.org/entity/Q35859412

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Dimethyl fumarate in multiple sclerosis: latest developments, evidence and place in therapy Mitochondria, cholesterol and cancer cell metabolism Targets for therapy in sarcomeric cardiomyopathies NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea.Different Contribution of Redox-Sensitive Transient Receptor Potential Channels to Acetaminophen-Induced Death of Human Hepatoma Cell Line.The complexity of the Nrf2 pathway: beyond the antioxidant response Mechanisms of oxidative damage in multiple sclerosis and neurodegenerative diseases: therapeutic modulation via fumaric acid esters Cytoprotection "gone astray": Nrf2 and its role in cancer The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders Dimethyl fumarate protects pancreatic islet cells and non-endocrine tissue in L-arginine-induced chronic pancreatitis α-Lipoic acid reduces infarct size and preserves cardiac function in rat myocardial ischemia/reperfusion injury through activation of PI3K/Akt/Nrf2 pathway.The succinated proteome.Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics.European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).Dimethylfumarate attenuates restenosis after acute vascular injury by cell-specific and Nrf2-dependent mechanisms The role of Nrf2-mediated pathway in cardiac remodeling and heart failure.Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.Activating Nrf-2 signaling depresses unilateral ureteral obstruction-evoked mitochondrial stress-related autophagy, apoptosis and pyroptosis in kidney.Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.Protection against myocardial ischemia-reperfusion injury at onset of type 2 diabetes in Zucker diabetic fatty rats is associated with altered glucose oxidation.Fumaric acid esters stimulate astrocytic VEGF expression through HIF-1α and Nrf2.Dimethyl fumarate ameliorates acute pancreatitis in rodent.Treatment With Dimethyl Fumarate Attenuates Calcineurin Inhibitor-induced Nephrotoxicity.Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway.Monomethyl fumarate promotes Nrf2-dependent neuroprotection in retinal ischemia-reperfusion Protective Effects of L-Malate against Myocardial Ischemia/Reperfusion Injury in Rats Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome.Loss of myocardial protection against myocardial infarction in middle-aged transgenic mice overexpressing cardiac thioredoxin-1 Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity.The emerging role of the Nrf2-Keap1 signaling pathway in cancer Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model.Changing appetites: the adaptive advantages of fuel choice.Nrf2 and cardiovascular defense.Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases.Molecular pharmacodynamics of new oral drugs used in the treatment of multiple sclerosis Heme oxygenase-1: an emerging therapeutic target to curb cardiac pathology.Plumericin inhibits proliferation of vascular smooth muscle cells by blocking STAT3 signaling via S-glutathionylation.Protection effect of nicotinamide on cardiomyoblast hypoxia/re-oxygenation injury: study of cellular mitochondrial metabolism.Opposing effects of Nrf2 and Nrf2-activating compounds on the NLRP3 inflammasome independent of Nrf2-mediated gene expression.

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Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

http://www.wikidata.org/entity/Q35859412

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name

Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

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Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

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type

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Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

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Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

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Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

@ast

Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

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J.CMET.2012.01.017

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Cell Metabolism

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Alan J Robinson

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Charles Redwood

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Christian Ludwig

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Daniel R Ball

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Henrik Isackson

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Hussain Contractor

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Iain Hargreaves

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Ismayil Ahmet

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John Land

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Jonathan J Byrne

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P2860

Cytoscape: a software environment for integrated models of biomolecular interaction networks

Nrf2-Keap1 defines a physiologically important stress response mechanism

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

Broccoli: a unique vegetable that protects mammalian hearts through the redox cycling of the thioredoxin superfamily

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway

Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

Genetic analysis of cytoprotective functions supported by graded expression of Keap1

Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation.

A metabolic model of the mitochondrion and its use in modelling diseases of the tricarboxylic acid cycle.

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Mogens Johannsen

Jennifer A. Kirwan

Anthony C Smith

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Rajesh K Kharbanda

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2012-03-01T00:00:00Z

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