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Genetic analysis of cytoprotective functions supported by graded expression of Keap1

Genetic analysis of cytoprotective functions supported by graded expression of Keap1

http://www.wikidata.org/entity/Q33877576

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Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2 Role of Nrf2 in oxidative stress and toxicity Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity.Nrf2 enhances cholangiocyte expansion in Pten-deficient livers Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury.Keap1 modulates the redox cycle and hepatocyte cell cycle in regenerating liver.Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes NRF2 and cancer: the good, the bad and the importance of context.Nrf2 affects the efficiency of mitochondrial fatty acid oxidation.Activation of the Nrf2-ARE pathway in hepatocytes protects against steatosis in nutritionally induced non-alcoholic steatohepatitis in mice Beneficial role of Nrf2 in regulating NADPH generation and consumption.Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: the protective role of the Keap1/Nrf2/ARE pathway.Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.Nrf2 links epidermal barrier function with antioxidant defense Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation Oxidative stress response and Nrf2 signaling in aging.Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet.Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma.The Keap1-Nrf2 system prevents onset of diabetes mellitus.Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration.Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding Notch-Nrf2 axis: regulation of Nrf2 gene expression and cytoprotection by notch signaling.Keap1 inhibition attenuates glomerulosclerosis.Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus.The cytoprotective role of the Keap1-Nrf2 pathway.Nrf2: control of sensitivity to carcinogens.Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases.Molecular and chemical regulation of the Keap1-Nrf2 signaling pathway.Association of Nrf2 with airway pathogenesis: lessons learned from genetic mouse models.Nrf2 regulates cellular behaviors and Notch signaling in oral squamous cell carcinoma cells.Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells.Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression.

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P2860

Genetic analysis of cytoprotective functions supported by graded expression of Keap1

http://www.wikidata.org/entity/Q33877576

description

2010 nî lūn-bûn

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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի ապրիլին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

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2010年論文

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2010年论文

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name

Genetic analysis of cytoprotective functions supported by graded expression of Keap1

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Genetic analysis of cytoprotective functions supported by graded expression of Keap1

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type

label

Genetic analysis of cytoprotective functions supported by graded expression of Keap1

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Genetic analysis of cytoprotective functions supported by graded expression of Keap1

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prefLabel

Genetic analysis of cytoprotective functions supported by graded expression of Keap1

@ast

Genetic analysis of cytoprotective functions supported by graded expression of Keap1

@en

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P1433

Molecular and Cellular Biology

P1476

Genetic analysis of cytoprotective functions supported by graded expression of Keap1

@en

P2093

Hozumi Motohashi

http://www.w3.org/2001/XMLSchema#string

Jonathan M Maher

http://www.w3.org/2001/XMLSchema#string

Keiko Taguchi

http://www.w3.org/2001/XMLSchema#string

Masayuki Yamamoto

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Yukie Kawatani

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P2860

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

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3016-3026

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scholarly article

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10.1128/MCB.01591-09

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12

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30

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Takafumi Suzuki

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2010-04-19T00:00:00Z

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20404090

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2876677

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