APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.
about
Protein oxidation, UVA and human DNA repairCancer drug resistance: redox resetting renders a wayDNA repair targeted therapy: The past or future of cancer treatment?Human AP endonuclease 1: a potential marker for the prediction of environmental carcinogenesis riskBiological Chemistry and Functionality of Protein Sulfenic Acids and Related Thiol ModificationsIdentification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor.Cardiac Cell Senescence and Redox Signaling.DNA damage related crosstalk between the nucleus and mitochondria.Suppression of choroidal neovascularization through inhibition of APE1/Ref-1 redox activity.Targeting DNA repair pathways for cancer treatment: what's new?Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathyFunctional analysis of tanshinone IIA that blocks the redox function of human apurinic/apyrimidinic endonuclease 1/redox factor-1.APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination.Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway.Functional assessment of population and tumor-associated APE1 protein variantsSpecific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell linesApurinic/apyrimidinic endonuclease 1 induced upregulation of fibroblast growth factor 2 and its receptor 3 induces angiogenesis in human osteosarcoma cells.Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization.Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor propertiesSmall-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer.Resistance exercise training increase activation of AKT-eNOS and Ref-1 expression by FOXO-1 activation in aorta of F344 ratsApurinic/apyrimidinic endonuclease 1 regulates angiogenesis in a transforming growth factor β-dependent manner in human osteosarcomaPersistent damage induces mitochondrial DNA degradation.Control of Trx1 redox state modulates protection against methyl methanesulfonate-induced DNA damage via stabilization of p21.Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited.Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation.17β-Estradiol alters oxidative stress response protein expression and oxidative damage in the uterus.Human apurinic/apyrimidinic endonuclease 1.Low-fidelity compensatory backup alternative DNA repair pathways may unify current carcinogenesis theories.Conferring specificity in redox pathways by enzymatic thiol/disulfide exchange reactions.Tumor-associated APE1 variant exhibits reduced complementation efficiency but does not promote cancer cell phenotypes.Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity.Structure-based virtual screening toward the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1.Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models.Apurinic/apyrimidinic endonuclease 1 (APE1/Ref-1) overexpression is an independent prognostic marker in prostate cancer without TMPRSS2:ERG fusion.Ref-1/APE1 as a Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia.Nanoparticle mediated silencing of DNA repair sensitizes pediatric brain tumor cells to γ-irradiation.Impact of apurinic/apyrimidinic endonuclease 1/redox factor-1 on treatment response and survival in oral squamous cell carcinoma.Design and synthesis of 3-carbamoylbenzoic acid derivatives as inhibitors of human apurinic/apyrimidinic endonuclease 1 (APE1).Fusion between M2-macrophages and cancer cells results in a subpopulation of radioresistant cells with enhanced DNA-repair capacity.
P2860
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P2860
APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
APE1/Ref-1 role in redox signa ...... pair/redox protein APE1/Ref-1.
@ast
APE1/Ref-1 role in redox signa ...... pair/redox protein APE1/Ref-1.
@en
type
label
APE1/Ref-1 role in redox signa ...... pair/redox protein APE1/Ref-1.
@ast
APE1/Ref-1 role in redox signa ...... pair/redox protein APE1/Ref-1.
@en
prefLabel
APE1/Ref-1 role in redox signa ...... pair/redox protein APE1/Ref-1.
@ast
APE1/Ref-1 role in redox signa ...... pair/redox protein APE1/Ref-1.
@en
P2860
P1476
APE1/Ref-1 role in redox signa ...... epair/redox protein APE1/Ref-1
@en
P2093
Mark R Kelley
P2860
P356
10.2174/1874467211205010036
P577
2012-01-01T00:00:00Z