A new strategy to decrease N-methyl-D-aspartate (NMDA) receptor coactivation: inhibition of D-serine synthesis by converting serine racemase into an eliminase.
about
Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serineCrystal Structure of a Homolog of Mammalian Serine Racemase from Schizosaccharomyces pombeMouse brain serine racemase catalyzes specific elimination of L-serine to pyruvateModulation of D-serine levels via ubiquitin-dependent proteasomal degradation of serine racemaseSerine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activityDirect calcium binding results in activation of brain serine racemaseAstrocyte-induced synaptogenesis is mediated by transforming growth factor β signaling through modulation of D-serine levels in cerebral cortex neuronsThe cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.d-serine levels in Alzheimer's disease: implications for novel biomarker developmentThe N-methyl D-aspartate receptor glycine site and D-serine metabolism: an evolutionary perspectiveParadoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis.D-amino acids in the brain: the biochemistry of brain serine racemase.D-amino acids in the brain: structure and function of pyridoxal phosphate-dependent amino acid racemases.Serine racemase: an unconventional enzyme for an unconventional transmitter.Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function.FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine.D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO).Treponema denticola cystalysin exhibits significant alanine racemase activity accompanied by transamination: mechanistic implications.SRR intronic variation inhibits expression of its neighbouring SMG6 gene and protects against temporal lobe epilepsy.Astrocytes are involved in trigeminal dynamic mechanical allodynia: potential role of D-serine.Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus musculusAntinociceptive effect of rat D-serine racemase inhibitors, L-serine-O-sulfate, and L-erythro-3-hydroxyaspartate in an arthritic pain model
P2860
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P2860
A new strategy to decrease N-methyl-D-aspartate (NMDA) receptor coactivation: inhibition of D-serine synthesis by converting serine racemase into an eliminase.
description
2001 nî lūn-bûn
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2001年の論文
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2001年論文
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2001年論文
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2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
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2001年论文
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name
A new strategy to decrease N-m ...... ne racemase into an eliminase.
@ast
A new strategy to decrease N-m ...... ne racemase into an eliminase.
@en
type
label
A new strategy to decrease N-m ...... ne racemase into an eliminase.
@ast
A new strategy to decrease N-m ...... ne racemase into an eliminase.
@en
prefLabel
A new strategy to decrease N-m ...... ne racemase into an eliminase.
@ast
A new strategy to decrease N-m ...... ne racemase into an eliminase.
@en
P2093
P2860
P356
P1476
A new strategy to decrease N-m ...... ne racemase into an eliminase.
@en
P2093
De Miranda J
Engelender S
Panizzutti R
Ribeiro CS
Wolosker H
P2860
P304
P356
10.1073/PNAS.091002298
P407
P577
2001-04-17T00:00:00Z