How conformational dynamics of DNA polymerase select correct substrates: experiments and simulations.
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Conformational selection in protein binding and functionEnzyme Selectivity of HIV Reverse Transcriptase: Conformations, Ligands, and Free Energy PartitionExploring the conformational transitions of biomolecular systems using a simple two-state anisotropic network modelDNA Mismatch Synthesis Complexes Provide Insights into Base Selectivity of a B Family DNA PolymeraseRevisiting Molecular Dynamics on a CPU/GPU system: Water Kernel and SHAKE ParallelizationRB69 DNA polymerase structure, kinetics, and fidelity.Biophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors.Investigations of α-helix↔β-sheet transition pathways in a miniprotein using the finite-temperature string methodIncreasing occurrences and functional roles for high energy purine-pyrimidine base-pairs in nucleic acidsA Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated VariantConformational dynamics of Thermus aquaticus DNA polymerase I during catalysis.Modeling kinetics and equilibrium of membranes with fields: milestoning analysis and implication to permeation."Gate-keeper" residues and active-site rearrangements in DNA polymerase μ help discriminate non-cognate nucleotides.Mechanism of substrate translocation by a ring-shaped ATPase motor at millisecond resolutionMolecular dynamics studies of modular polyketide synthase ketoreductase stereospecificity.Molecular dynamics simulation in virus research.Intermediate state trapping of a voltage sensorPerspective: Computer simulations of long time dynamicsPerspective: pre-chemistry conformational changes in DNA polymerase mechanismsThumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase Allosterically Block the Transition from Initiation to ElongationVaccine-derived mutation in motif D of poliovirus RNA-dependent RNA polymerase lowers nucleotide incorporation fidelity.Computational simulation strategies for analysis of multisubunit RNA polymerases.Why nature really chose phosphate.A century of enzyme kinetic analysis, 1913 to 2013.A new general method for simultaneous fitting of temperature and concentration dependence of reaction rates yields kinetic and thermodynamic parameters for HIV reverse transcriptase specificity.Path-sampling strategies for simulating rare events in biomolecular systems.Whether 2-aminopurine induces incorporation errors at the DNA replication? A quantum-mechanical answer on the actual biological issue.Rate-limiting Pyrophosphate Release by HIV Reverse Transcriptase Improves Fidelity.HIV-1 Reverse Transcriptase Polymerase and RNase H (Ribonuclease H) Active Sites Work Simultaneously and Independently.Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase.Triphosphate Reorientation of the Incoming Nucleotide as a Fidelity Checkpoint in Viral RNA-dependent RNA Polymerases.A novel conception for spontaneous transversions caused by homo-pyrimidine DNA mismatches: a QM/QTAIM highlight.Computational study of peptide permeation through membrane: Searching for hidden slow variables.Tautomeric transition between wobble A·C DNA base mispair and Watson-Crick-like A·C* mismatch: microstructural mechanism and biological significance.FRET-based assay to screen inhibitors of HIV-1 reverse transcriptase and nucleocapsid protein.How many tautomerization pathways connect Watson-Crick-like G*·T DNA base mispair and wobble mismatches?Evidence of ternary complex formation in Trypanosoma cruzi trans-sialidase catalysisExact milestoning.Exploring the mechanism of DNA polymerases by analyzing the effect of mutations of active site acidic groups in Polymerase βC(α) torsion angles as a flexible criterion to extract secrets from a molecular dynamics simulation.
P2860
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P2860
How conformational dynamics of DNA polymerase select correct substrates: experiments and simulations.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
How conformational dynamics of ...... : experiments and simulations.
@ast
How conformational dynamics of ...... : experiments and simulations.
@en
type
label
How conformational dynamics of ...... : experiments and simulations.
@ast
How conformational dynamics of ...... : experiments and simulations.
@en
prefLabel
How conformational dynamics of ...... : experiments and simulations.
@ast
How conformational dynamics of ...... : experiments and simulations.
@en
P2093
P2860
P1433
P1476
How conformational dynamics of ...... : experiments and simulations.
@en
P2093
Kenneth A Johnson
Serdal Kirmizialtin
Virginia Nguyen
P2860
P304
P356
10.1016/J.STR.2012.02.018
P577
2012-04-03T00:00:00Z