about
K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanismFidelity of DNA synthesis catalyzed by human DNA polymerase alpha and HIV-1 reverse transcriptase: effect of reaction pHRNase H activity: structure, specificity, and function in reverse transcriptionMechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitorsRibonuclease H: properties, substrate specificity and roles in retroviral reverse transcriptionStable complexes formed by HIV-1 reverse transcriptase at distinct positions on the primer-template controlled by binding deoxynucleoside triphosphates or foscarnetFunctional roles of carboxylate residues comprising the DNA polymerase active site triad of Ty3 reverse transcriptaseNucleotide modification at the gamma-phosphate leads to the improved fidelity of HIV-1 reverse transcriptase.Enzyme Selectivity of HIV Reverse Transcriptase: Conformations, Ligands, and Free Energy PartitionStructural basis for activation of α-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptaseStructures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir ResistanceA mechanistic and structural investigation of modified derivatives of the diaryltriazine class of NNRTIs targeting HIV-1 reverse transcriptaseStructures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavageAssembly, purification, and pre-steady-state kinetic analysis of active RNA-dependent RNA polymerase elongation complexMechanistic differences in RNA-dependent DNA polymerization and fidelity between murine leukemia virus and HIV-1 reverse transcriptasesMechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTPSelection and characterization of human immunodeficiency virus type 1 variants resistant to the (+) and (-) enantiomers of 2'-deoxy-3'-oxa-4'-thio-5-fluorocytidineSelective interaction of the human immunodeficiency virus type 1 reverse transcriptase nonnucleoside inhibitor efavirenz and its thio-substituted analog with different enzyme-substrate complexesLow levels of deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit human immunodeficiency virus type 1 replicationMode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerasesN348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistanceMechanisms of activity and inhibition of the hepatitis C virus RNA-dependent RNA polymerase.Analysis of RNA base modification and structural rearrangement by single-molecule real-time detection of reverse transcription.Host sequence motifs shared by HIV predict response to antiretroviral therapyAllosteric regulation of HIV-1 reverse transcriptase by ATP for nucleotide selection.Coordination between the polymerase and RNase H activity of HIV-1 reverse transcriptaseReal time measurements of elongation by a reverse transcriptase using surface plasmon resonance.Biophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors.Multiple nucleotide preferences determine cleavage-site recognition by the HIV-1 and M-MuLV RNases H.Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation.A novel hemagglutinin with antiproliferative activity against tumor cells from the hallucinogenic mushroom Boletus speciosus.Fidelity of Nucleotide Incorporation by the RNA-Dependent RNA Polymerase from Poliovirus.Factors that determine the efficiency of HIV-1 strand transfer initiated at a specific siteNucleotide-dependent conformational change governs specificity and analog discrimination by HIV reverse transcriptase.Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.Monitoring patients with HIV diseaseDNA synthesis fidelity by the reverse transcriptase of the yeast retrotransposon Ty1.Dynamic copy choice: steady state between murine leukemia virus polymerase and polymerase-dependent RNase H activity determines frequency of in vivo template switching.Human immunodeficiency virus mutagenesis during antiviral therapy: impact of drug-resistant reverse transcriptase and nucleoside and nonnucleoside reverse transcriptase inhibitors on human immunodeficiency virus type 1 mutation frequencies.
P2860
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P2860
description
1992 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1992
@ast
im Dezember 1992 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1992/12/25)
@sk
vědecký článek publikovaný v roce 1992
@cs
wetenschappelijk artikel (gepubliceerd op 1992/12/25)
@nl
наукова стаття, опублікована в грудні 1992
@uk
name
Mechanism and fidelity of HIV reverse transcriptase
@ast
Mechanism and fidelity of HIV reverse transcriptase
@en
Mechanism and fidelity of HIV reverse transcriptase
@nl
type
label
Mechanism and fidelity of HIV reverse transcriptase
@ast
Mechanism and fidelity of HIV reverse transcriptase
@en
Mechanism and fidelity of HIV reverse transcriptase
@nl
prefLabel
Mechanism and fidelity of HIV reverse transcriptase
@ast
Mechanism and fidelity of HIV reverse transcriptase
@en
Mechanism and fidelity of HIV reverse transcriptase
@nl
P2093
P1476
Mechanism and fidelity of HIV reverse transcriptase
@en
P2093
K. A. Johnson
K. S. Anderson
L. F. Jerva
W. M. Kati
P304
25988–25997
P407
P577
1992-12-25T00:00:00Z