Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus. - Wikidata - wikimedia - TriplyDB

Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus.

Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus.

http://www.wikidata.org/entity/Q35879514

about

In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation Systems biology of lupus: mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment.Defective B-cell response to T-dependent immunization in lupus-prone mice Pathogenic mechanisms in systemic lupus erythematosus.Emerging new pathways of pathogenesis and targets for treatment in systemic lupus erythematosus and Sjogren's syndrome.Oxidative stress in the pathology and treatment of systemic lupus erythematosus T-cell and B-cell signaling biomarkers and treatment targets in lupus.Gene network analysis of bone marrow mononuclear cells reveals activation of multiple kinase pathways in human systemic lupus erythematosus.Autoreactive marginal zone B cells enter the follicles and interact with CD4+ T cells in lupus-prone mice.Activation of rheumatoid factor-specific B cells is antigen dependent and occurs preferentially outside of germinal centers in the lupus-prone NZM2410 mouse model Prolonged effects of short-term anti-CD20 B cell depletion therapy in murine systemic lupus erythematosus.Systemic lupus erythematosus and increased risk to develop B cell malignancies: role of the p200-family proteins.Requirements for innate immune pathways in environmentally induced autoimmunity.SLE peripheral blood B cell, T cell and myeloid cell transcriptomes display unique profiles and each subset contributes to the interferon signature Evidence of dynamically dysregulated gene expression pathways in hyperresponsive B cells from African American lupus patients.Green tea polyphenol (-)-epigallocatechin-3-gallate restores Nrf2 activity and ameliorates crescentic glomerulonephritis The transcription factor Bright plays a role in marginal zone B lymphocyte development and autoantibody production.Interferon-inducible Ifi200-family genes as modifiers of lupus susceptibility.RNA-seq Analysis Reveals Unique Transcriptome Signatures in Systemic Lupus Erythematosus Patients with Distinct Autoantibody Specificities Prevention of murine lupus nephritis by targeting multiple signaling axes and oxidative stress using a synthetic triterpenoid.Urinary angiostatin--a novel putative marker of renal pathology chronicity in lupus nephritis.Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus.Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus Protein kinase Cβ is required for lupus development in Sle mice Altered B cell receptor signaling in human systemic lupus erythematosus Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases.Epigallocatechin-3-gallate (EGCG) attenuates inflammation in MRL/lpr mouse mesangial cells.B-lymphocyte signalling abnormalities and lupus immunopathology.B-lymphocyte tolerance and effector function in immunity and autoimmunity.Immunometabolism in systemic lupus erythematosus.Differential effects of rapamycin in anti-GBM glomerulonephritis.Signal transducer and activator of transcription (STAT) 3 inhibition delays the onset of lupus nephritis in MRL/lpr mice.Characterization of the metabolic phenotype of chronically activated lymphocytes.Review: Metabolic Control of Immune System Activation in Rheumatic Diseases.B Cell-Intrinsic mTORC1 Promotes Germinal Center-Defining Transcription Factor Gene Expression, Somatic Hypermutation, and Memory B Cell Generation in Humoral Immunity.Metabolic Reprogramming Commits Differentiation of Human CD27+IgD+ B Cells to Plasmablasts or CD27-IgD- Cells.PKK deficiency in B cells prevents lupus development in Sle lupus mice.The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by rapamycin.Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance.Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus

P2860

Q24610713-9F104D7E-53D7-43B2-B119-4AA92EC2068A Q33608479-46AA7B0D-B150-4BD5-A92F-36E0F8E63DD6 Q33689667-7AFF0CFD-3E2A-43D3-9FE5-BD73EC05653C Q33715441-D5292CEB-D1ED-43BA-9AD3-AFB3CC05A815 Q33715480-DFF40193-305C-478E-8B2B-32FD1E648892 Q33715508-D4B6E643-A5B8-4AF1-848F-FF3E98037C8A Q33718893-9EEC182F-2764-4BB4-B4C5-0A9A7248ED0B Q33728674-78FE7AAB-44D0-47C1-B187-E135E0C98A4E Q33798580-2E73E746-DDF0-4454-82E6-72B8DDCF2FE3 Q33992536-B1216EBA-0853-474D-B6C5-99C60FE8140F Q34063315-A42C33A0-60EC-4E50-AE81-DFBBABF33A0B Q34079465-39008431-001C-4D58-AABB-EF32C35352CD Q34655526-FEF2CB53-0458-4AE2-A596-E52B4F06F4BD Q34796327-08EA8DDE-CB96-4BF3-832D-E728AF269549 Q34971055-F4F61163-2FD7-404E-BD9C-2D63F3541D8A Q35191850-CBDA0B9C-21E6-4639-B8A8-AD42560EA14A Q35490321-589F4414-6A94-41C8-BBEF-9B394AAEEBE5 Q36183169-2D5CC6CC-B3CB-45AB-A0C8-3DA366EF4818 Q36190001-2640EB8E-474E-44B4-8C20-304948C0EC4A Q36823420-C1CA40E3-61E6-4CE2-8D17-6D193B5204A7 Q36832462-0039E687-8216-4F39-934D-C58A7FD8C120 Q36907698-E985503A-5091-445C-B658-18C968CEE7BC Q37065111-1915D887-785D-4F84-8CC3-5D5131E82782 Q37146459-02742021-87C4-4AB4-B6B2-3E605E852526 Q37250671-AB183E16-2967-48D3-B052-E0369DDE1884 Q37649641-AEC90F99-D0A8-4E05-BEB8-001DC34D5754 Q37727280-6AFDF87A-000E-459A-A3DE-11578754887A Q38114500-F2DFE611-EB54-47EB-A1D5-AC8394560A86 Q38167667-FDE1F457-36FE-4112-BB18-71F4D8AD52DA Q39209701-123A7F61-C202-49CA-A8C6-FCEEA5630A2C Q41066466-3782CD83-DA99-4883-8F37-538269CBA581 Q41831402-6856E2B8-5D16-461A-8F4C-D98C85210AF3 Q42963724-60241C99-57C3-485C-9E98-88A8A790A729 Q47133379-911D8E75-1D24-4334-B69D-E25F7F7C204E Q50531025-57819741-5B6F-42D6-A033-3A3A0D51FCA1 Q50579001-0002AA81-D1B2-400D-AAA1-0BA5710E2869 Q50678340-388BC44A-32B9-4BED-B145-A233CBFFF3E3 Q51547435-70CE79B9-A23C-456C-A7C7-DDB4D2EA2A47 Q54114681-05050189-5AF7-4C79-BD62-0A61FB9201EC Q59126360-4A34CAF3-7108-4637-803C-E186C0D0C17E

P2860

Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus.

http://www.wikidata.org/entity/Q35879514

description

2007 nî lūn-bûn

@nan

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

2007年论文

@zh

2007年论文

@zh-cn

name

Shared signaling networks acti ...... istinct mouse models of lupus.

@ast

Shared signaling networks acti ...... istinct mouse models of lupus.

@en

type

label

Shared signaling networks acti ...... istinct mouse models of lupus.

@ast

Shared signaling networks acti ...... istinct mouse models of lupus.

@en

prefLabel

Shared signaling networks acti ...... istinct mouse models of lupus.

@ast

Shared signaling networks acti ...... istinct mouse models of lupus.

@en

P1433

Q35879514-F3128189-F5E0-438A-B6EF-22F43B0C17E0

P1476

Q35879514-BDCD46FF-2EC5-4DDA-A87B-24603D40A829

P2093

Q35879514-51914DF2-56EB-4DE2-9212-5D2DBDD487F5

Q35879514-64C3EB97-50D7-4DB5-A89F-FFE1AA20DB4C

Q35879514-85D3DD83-D233-4C60-B78D-E875558A265A

Q35879514-A92A61F0-AB4F-41CF-B947-919B0E27B51A

Q35879514-AD7285F5-2CAD-48DB-A799-4C9EA3E54CFE

Q35879514-BA33681C-12E5-42F5-AD53-F34C8E489C8C

Q35879514-C4D9CEF1-395E-4F7C-811D-B0EEF25D8B0D

Q35879514-C8DF8059-DE79-410E-9E56-C501B015E17E

Q35879514-DC47ABF2-2BE7-4646-B84C-0DACFD6A4D81

P2860

Q35879514-0CABE8D4-C152-4DE7-9CAC-283BF4D77BE1

Q35879514-0DCFEF9D-2FEE-4C2C-8AEC-1A6D7B5594C3

Q35879514-115FD26A-0297-4059-8192-2682255B727F

Q35879514-11AC494C-D951-47F5-B368-BD0455F941BE

Q35879514-1289F979-3247-4CC5-B94F-282214C742C2

Q35879514-149E4DAD-9003-40F3-842B-6AAC1E69CD86

Q35879514-152B248F-54A3-4654-806F-E8F154E09585

Q35879514-1543EBC7-04DD-41D5-AA05-B9955F243434

Q35879514-1724BD3C-8C49-4BEB-BA9F-E10275B21C55

Q35879514-2637DB71-9F6A-4372-8DE6-CCE73CCB3C74

P304

Q35879514-6A87215B-12B6-4F5C-82EB-8EC095F870EE

P31

Q35879514-C31D3C38-1432-41D3-8EA4-E7B6956822D3

P356

Q35879514-A6048E7D-1B8C-4E0C-B11E-3BDCA13C1779

P407

Q35879514-1A9B5A6A-4C2E-48B2-BBA9-684349C632DF

P433

Q35879514-594B7B8C-0F42-465F-BB67-7ADD206877BA

P478

Q35879514-BBCC4AFC-80F3-4EA3-9714-351BCBDE6F8F

P50

Q35879514-13D0982F-6BF9-4710-B12E-CFCA29C6FB04

P577

Q35879514-8BB09C50-746C-44FE-A416-7BBE61FB42E7

P698

Q35879514-5FBB79D2-E27B-4E18-B372-4AF920E15ABB

P932

Q35879514-2E377CD6-4F88-4C59-92AE-F6D1DDF94246

P356

P1433

Journal of Clinical Investigation

P1476

Shared signaling networks acti ...... distinct mouse models of lupus

@en

P2093

Anne B Satterthwaite

http://www.w3.org/2001/XMLSchema#string

Chandra Mohan

http://www.w3.org/2001/XMLSchema#string

Hasna Kanta

http://www.w3.org/2001/XMLSchema#string

Kirthi Raman Kumar

http://www.w3.org/2001/XMLSchema#string

Kui Liu

http://www.w3.org/2001/XMLSchema#string

Laurie S Davis

http://www.w3.org/2001/XMLSchema#string

Xiangmei Qin

http://www.w3.org/2001/XMLSchema#string

Xin J Zhou

http://www.w3.org/2001/XMLSchema#string

Zoran Kurepa

http://www.w3.org/2001/XMLSchema#string

P2860

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

TOR signaling in growth and metabolism

CDK inhibitors: positive and negative regulators of G1-phase progression

Current development of mTOR inhibitors as anticancer agents

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

Ras, PI(3)K and mTOR signalling controls tumour cell growth

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

P304

2186-2196

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1172/JCI30398

http://www.w3.org/2001/XMLSchema#string

P407

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

117

http://www.w3.org/2001/XMLSchema#string

P50

P577

2007-08-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

17641780

http://www.w3.org/2001/XMLSchema#string

P932

1913486

http://www.w3.org/2001/XMLSchema#string