Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). - Wikidata - wikimedia - TriplyDB

Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A).

Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A).

http://www.wikidata.org/entity/Q35879636

about

Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer's Disease Zinc and the modulation of redox homeostasis Modulation of tau phosphorylation by environmental copper.Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau.Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation.K+ efflux agonists induce NLRP3 inflammasome activation independently of Ca2+ signaling.A time-course analysis of changes in cerebral metal levels following a controlled cortical impact.Roles of phosphotase 2A in nociceptive signal processing.Tau-induced neurodegeneration: mechanisms and targets.Glia and zinc in ageing and Alzheimer's disease: a mechanism for cognitive decline?Traumatic Brain Injury, Chronic Traumatic Encephalopathy, and Alzheimer's Disease: Common Pathologies Potentiated by Altered Zinc Homeostasis.Behind the curtain of tauopathy: a show of multiple players orchestrating tau toxicity.Morroniside-Induced PP2A Activation Antagonizes Tau Hyperphosphorylation in a Cellular Model of Neurodegeneration.MicroRNA-34c Downregulation Ameliorates Amyloid-β-Induced Synaptic Failure and Memory Deficits by Targeting VAMP2.Zinc mediates the neuronal activity-dependent anti-apoptotic effect.Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation.COX-2 metabolic products, the prostaglandin I2 and F2α, mediate the effects of TNF-α and Zn2+ in stimulating the phosphorylation of Tau.Zinc Signal in Brain Diseases.Metal Ion Effects on Aβ and Tau Aggregation.Zinc regulates expression of IL-23 p19 mRNA via activation of eIF2α/ATF4 axis in HAPI cells.Cornel Iridoid Glycoside Inhibits Tau Hyperphosphorylation via Regulating Cross-Talk Between GSK-3β and PP2A Signaling.Lactate transport facilitates neurite outgrowth Tau Pathology in Parkinson's Disease

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Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A).

http://www.wikidata.org/entity/Q35879636

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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name

Synaptic released zinc promote ...... protein phosphatase 2A (PP2A).

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Synaptic released zinc promote ...... protein phosphatase 2A (PP2A).

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Synaptic released zinc promote ...... protein phosphatase 2A (PP2A).

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Synaptic released zinc promote ...... protein phosphatase 2A (PP2A).

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Synaptic released zinc promote ...... protein phosphatase 2A (PP2A).

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JBC.M111.309070

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Journal of Biological Chemistry

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Synaptic released zinc promote ...... protein phosphatase 2A (PP2A)

@en

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Ao-Ji Xie

http://www.w3.org/2001/XMLSchema#string

Jian-Zhi Wang

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Qun Wang

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Xiao-Chuan Wang

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Xiu-Lian Wang

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Xu-Ying Sun

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Yan Xiong

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Yang Yang

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You-Ming Lu

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Yu-Ping Wei

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P2860

Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40

Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit

Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease

Alzheimer disease: progress or profit?

Synaptically released zinc: physiological functions and pathological effects.

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

Phosphoprotein phosphatase activities in Alzheimer disease brain.

Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease.

Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain.

Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration.

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11174-11182

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10.1074/JBC.M111.309070

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2012-02-10T00:00:00Z

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221832688

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3322889

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