Alteration of a single serine in the basic domain of the Epstein-Barr virus ZEBRA protein separates its functions of transcriptional activation and disruption of latency.
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Paleo-immunology: evidence consistent with insertion of a primordial herpes virus-like element in the origins of acquired immunityMethyl-dependent and spatial-specific DNA recognition by the orthologous transcription factors human AP-1 and Epstein-Barr virus ZtaA subset of replication proteins enhances origin recognition and lytic replication by the Epstein-Barr virus ZEBRA protein.Activation of the Epstein-Barr virus transcription factor BZLF1 by 12-O-tetradecanoylphorbol-13-acetate-induced phosphorylation.The Epstein-Barr virus lytic transactivator Zta interacts with the helicase-primase replication proteins.Genetic dissection of cell growth arrest functions mediated by the Epstein-Barr virus lytic gene product, ZtaBZLF1 activation of the methylated form of the BRLF1 immediate-early promoter is regulated by BZLF1 residue 186.Autostimulation of the Epstein-Barr virus BRLF1 promoter is mediated through consensus Sp1 and Sp3 binding sites.Activation and repression of Epstein-Barr Virus and Kaposi's sarcoma-associated herpesvirus lytic cycles by short- and medium-chain fatty acidsA locus encompassing the Epstein-Barr virus bglf4 kinase regulates expression of genes encoding viral structural proteinsEfficient induction of nuclear aggresomes by specific single missense mutations in the DNA-binding domain of a viral AP-1 homolog.Tegument protein control of latent herpesvirus establishment and animation.Amino acids in the basic domain of Epstein-Barr virus ZEBRA protein play distinct roles in DNA binding, activation of early lytic gene expression, and promotion of viral DNA replication.Differential gene regulation by selective association of transcriptional coactivators and bZIP DNA-binding domainsPhosphorylation of Epstein-Barr virus ZEBRA protein at its casein kinase 2 sites mediates its ability to repress activation of a viral lytic cycle late gene by Rta.Nuclear translocation and regulation of intranuclear distribution of cytoplasmic poly(A)-binding protein are distinct processes mediated by two Epstein Barr virus proteins.DNA Damage Signaling Is Induced in the Absence of Epstein-Barr Virus (EBV) Lytic DNA Replication and in Response to Expression of ZEBRA.Ser-634 and Ser-636 of Kaposi's Sarcoma-Associated Herpesvirus RTA are Involved in Transactivation and are Potential Cdk9 Phosphorylation Sites.Late gene expression from the Epstein-Barr virus BcLF1 and BFRF3 promoters does not require DNA replication in cis.The Epstein-Barr Virus Immunoevasins BCRF1 and BPLF1 Are Expressed by a Mechanism Independent of the Canonical Late Pre-initiation Complex.Latency of Epstein-Barr virus is disrupted by gain-of-function mutant cellular AP-1 proteins that preferentially bind methylated DNA.Early activation of the Kaposi's sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway.CCAAT/enhancer binding protein alpha binds to the Epstein-Barr virus (EBV) ZTA protein through oligomeric interactions and contributes to cooperative transcriptional activation of the ZTA promoter through direct binding to the ZII and ZIIIB motifs dThe Epstein-Barr virus Rta protein activates lytic cycle genes and can disrupt latency in B lymphocytesEssential role of Rta in lytic DNA replication of Epstein-Barr virusStimulation of CREB binding protein nucleosomal histone acetyltransferase activity by a class of transcriptional activators.Amino acid substitutions reveal distinct functions of serine 186 of the ZEBRA protein in activation of early lytic cycle genes and synergy with the Epstein-Barr virus R transactivatorRole of the epstein-barr virus RTA protein in activation of distinct classes of viral lytic cycle genes.Epstein-Barr virus LF2 protein regulates viral replication by altering Rta subcellular localization.Disruption of Epstein-Barr virus latency in the absence of phosphorylation of ZEBRA by protein kinase C.The CBP bromodomain and nucleosome targeting are required for Zta-directed nucleosome acetylation and transcription activation.Stimulus duration and response time independently influence the kinetics of lytic cycle reactivation of Epstein-Barr virus.Mutations of amino acids in the DNA-recognition domain of Epstein-Barr virus ZEBRA protein alter its sub-nuclear localization and affect formation of replication compartments.Mutation of a single amino acid residue in the basic region of the Epstein-Barr virus (EBV) lytic cycle switch protein Zta (BZLF1) prevents reactivation of EBV from latency.A redox-sensitive cysteine in Zta is required for Epstein-Barr virus lytic cycle DNA replication.Kaposi's sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinases.Unexpected structure of Epstein-Barr virus lytic cycle activator Zta.Evidence for DNA hairpin recognition by Zta at the Epstein-Barr virus origin of lytic replication.Epstein-Barr Virus-Induced Nodules on Viral Replication Compartments Contain RNA Processing Proteins and a Viral Long Noncoding RNA
P2860
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P2860
Alteration of a single serine in the basic domain of the Epstein-Barr virus ZEBRA protein separates its functions of transcriptional activation and disruption of latency.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Alteration of a single serine ...... ion and disruption of latency.
@ast
Alteration of a single serine ...... ion and disruption of latency.
@en
type
label
Alteration of a single serine ...... ion and disruption of latency.
@ast
Alteration of a single serine ...... ion and disruption of latency.
@en
prefLabel
Alteration of a single serine ...... ion and disruption of latency.
@ast
Alteration of a single serine ...... ion and disruption of latency.
@en
P2093
P2860
P1433
P1476
Alteration of a single serine ...... ion and disruption of latency.
@en
P2093
A L Francis
L Gradoville
P2860
P304
P407
P577
1997-04-01T00:00:00Z