Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes. - Wikidata - wikimedia - TriplyDB

Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes.

Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes.

http://www.wikidata.org/entity/Q35891952

about

Beta cell antigens in type 1 diabetes: triggers in pathogenesis and therapeutic targets Anti-Insulin Immune Responses Are Detectable in Dogs with Spontaneous Diabetes Concise Review: Cell-Based Therapies and Other Non-Traditional Approaches for Type 1 Diabetes Restoring immune tolerance in neuromyelitis optica: Part I Restoring the balance: immunotherapeutic combinations for autoimmune disease Combination therapy with an anti-IL-1β antibody and GAD65 DNA vaccine can reverse recent-onset diabetes in the RIP-GP mouse model.Progress and prospects of gene therapy clinical trials for the muscular dystrophies.Chemical tools to monitor and manipulate the adaptive immune system.Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97.Gene Therapy for Duchenne muscular dystrophy.Present and Future Therapies in Neuromyelitis Optica Spectrum Disorders Immune interventions to preserve β cell function in type 1 diabetes Profile of Lawrence Steinman.Clinical optimization of antigen specific modulation of type 1 diabetes with the plasmid DNA platform.Identification of Candidate Tolerogenic CD8(+) T Cell Epitopes for Therapy of Type 1 Diabetes in the NOD Mouse Model.Non-antigenic and antigenic interventions in type 1 diabetes Strategies for clinical trials in type 1 diabetes Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination A Journey in Science: The Privilege of Exploring the Brain and the Immune System.Efficient Presentation of Multiple Endogenous Epitopes to Both CD4+ and CD8+ Diabetogenic T Cells for Tolerance Programming of neuroendocrine self in the thymus and its defect in the development of neuroendocrine autoimmunity.Antigen-specific tolerization approaches in multiple sclerosis.The IL-2/IL-2R system: from basic science to therapeutic applications to enhance immune regulation.Treatment of new onset type 1 diabetes with teplizumab: successes and pitfalls in development.Metabolic syndrome - Removing roadblocks to therapy: Antigenic immunotherapies Development of therapies for autoimmune disease at Stanford: a tale of multiple shots and one goal.Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens.Biomarkers for antigen immunotherapy in allergy and type 1 diabetes.Addressing Unmet Medical Needs in Type 1 Diabetes: A Review of Drugs under Development.A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells.Antigen-specific immunotherapies in rheumatic diseases.Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2.Insulin B chain 9-23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs.Memory of tolerance and induction of regulatory T cells by erythrocyte-targeted antigens Immunological Balance Is Associated with Clinical Outcome after Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes.T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes.Have we pushed the needle for treatment of Type 1 diabetes?Immunotherapy: Modified proinsulin to treat T1DM.Pathophysiological characteristics of preproinsulin-specific CD8+ T cells in subjects with juvenile-onset and adult-onset type 1 diabetes: A 1-year follow-up study.APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice.

P2860

Q26751244-1A525CE3-8A3D-4BD2-A86A-877514AE3BAC Q27316266-85C34F44-5F32-4E37-A287-3B1294D96794 Q28071490-22E54B2A-7570-43FC-B141-93281621C488 Q28072382-A8EFF2CB-FA14-413E-9DEB-A3635C79A036 Q33555986-4F74FCD4-2175-4820-BFDF-C2C20F88260E Q33646749-B95C609D-7D91-4985-A4BE-F215642EE5AA Q34497471-6993CBFC-41C2-4941-B7C3-3E2AD65C66D9 Q35264291-BF710D80-CC87-44CC-9A92-6E01710E9C4D Q35672979-2BDD98CF-17A6-4985-9482-A3F89ABA4C84 Q36295934-7D07F10D-480A-4AEC-9DFF-EB24BCEF0F33 Q36484394-FAFCB75A-B21B-4EB8-A491-E91B8151E7B1 Q36520618-8C576417-848B-450B-B4D5-AD4A535DB869 Q36598882-3851CCCF-D390-4D28-B504-ED9F14B9C8DB Q36709163-E72EE416-1822-4124-B300-AB74BEB7BC91 Q36741859-1FA68518-18DE-4D1D-98B1-9D47C96686EF Q36977725-1E032A6E-9CF1-4CDD-89AD-A2AD55B07671 Q36995370-CAA50679-4884-46C2-B20F-50AB0CC2290B Q37089336-2AFC3296-36F6-4687-9D2D-FB25B3AAD194 Q37217037-55662AD5-FA6D-4CC3-B795-133A18BF9F1E Q37717905-E6539138-E3D1-4F74-B091-FBBBBCBEE75D Q38153686-AE4BBB60-4067-4B09-8FB4-A4AD735E656F Q38154948-BEEDEF4D-C418-4EA7-BDBA-4D63CC45FB04 Q38161439-BA8F6DF3-FD8B-4634-90C8-434BDE0EB607 Q38187146-FBB705B2-B1DF-4D0F-AC37-C83419B86D19 Q38205771-E2B1873B-3C89-4118-880A-E5B3D009F4ED Q38207555-C66C1C67-E572-442E-A733-5CF1F5914D4F Q38489669-5983C758-ECFE-4687-814F-748CCAC11C89 Q38539950-61365F43-D17F-46C6-A8A4-8A8B36D049C3 Q38806457-F42571F6-0047-4597-8F9D-E2526F44E3D8 Q38967091-3E6EBDDD-0CDF-4B2D-BA37-CAA846B111B5 Q39431371-E2571981-F729-4B3E-9174-7D96E9E33A1B Q39665315-115B51DA-0E05-4438-A4BE-4C6B1752869F Q40895314-91FFD452-68B8-42B0-B3ED-B04C793791C0 Q40933700-0FF78AB4-CDF5-4833-B7AC-390847BECFEE Q42320502-3434153B-11B6-433F-A881-75195B586D2F Q47093542-B7F8B475-E78A-417E-A433-4C1BB97DAFDE Q47907621-E76EFDF5-EFA1-4DA9-869D-576C65FD70E8 Q48002890-83FDD1C9-1AB3-4C5C-92D4-539C3570397D Q48166710-8A5A161B-483B-406F-9889-5C762A8EA403 Q48282619-9C73EE04-BED4-4AF8-A21E-A96FC3FC765F

P2860

Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes.

http://www.wikidata.org/entity/Q35891952

description

2013 nî lūn-bûn

@nan

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

2013年论文

@zh

2013年论文

@zh-cn

name

Plasmid-encoded proinsulin pre ...... 8⁺ T cells in type 1 diabetes.

@ast

Plasmid-encoded proinsulin pre ...... 8⁺ T cells in type 1 diabetes.

@en

type

label

Plasmid-encoded proinsulin pre ...... 8⁺ T cells in type 1 diabetes.

@ast

Plasmid-encoded proinsulin pre ...... 8⁺ T cells in type 1 diabetes.

@en

prefLabel

Plasmid-encoded proinsulin pre ...... 8⁺ T cells in type 1 diabetes.

@ast

Plasmid-encoded proinsulin pre ...... 8⁺ T cells in type 1 diabetes.

@en

P1433

Q35891952-3EB9684C-74EA-49F5-B5F5-1D06E600862B

P1476

Q35891952-96076C39-F3D1-4BA6-AB2E-58CB7952C16B

P2093

Q35891952-0B4B6D4B-22A3-4B04-ACAC-F8BE82B7BEAF

Q35891952-2798647C-67D0-40FC-9F84-1AF8C8896BDF

Q35891952-2A21479C-8AFD-49AB-916F-D442A0D5AD50

Q35891952-2B8EAB54-D84A-4B1E-AC5D-D3E989E10DB7

Q35891952-316F330F-E41A-4D8E-AA24-1A2A86ED8A26

Q35891952-39955429-CBF0-4D25-852D-951D6BB75276

Q35891952-4CA37EEB-15AA-4919-B64F-C5A308D37578

Q35891952-6480B20D-7491-4825-8151-424F07C8D1E8

Q35891952-67074197-EC34-4C7A-9F1F-42E935D9DB00

Q35891952-6A1C6FBF-7442-4BA7-A2EC-8E8E654846AF

P2860

Q35891952-0385A26D-F97E-4174-82B3-1EEF90736ED7

Q35891952-07C501C6-6B3A-43E6-9382-B36174C357F3

Q35891952-0D1CD6A5-348F-4A34-8F13-938AD6AEF607

Q35891952-15E7D459-3DCF-4D32-9099-4057FC31535B

Q35891952-1E2DDB3A-13F2-4853-91DB-0CC967519D61

Q35891952-1ECCEEE9-B040-4D4C-9980-1102E2061859

Q35891952-1EDA1FC5-64F3-44CE-90CD-38E08DFEDC00

Q35891952-33C71FAB-329A-4213-A094-F9D459A7E518

Q35891952-38C6CA07-2F09-4EA0-9FB5-67DD90400909

Q35891952-65E43544-04B5-4208-A207-858278FEF109

P304

Q35891952-FD831A81-629C-4F3D-853B-37B1E998EC53

P31

Q35891952-07BAC788-8337-4D26-BDB4-7144CCEBA412

P356

Q35891952-07F41DFA-6E21-49AE-B9B7-F9CE57EEA699

P407

Q35891952-A97E371C-4818-4CF7-A024-C5C6772ED42A

P433

Q35891952-61DBEDC6-0317-43E4-9BC7-C825E4C668EF

P478

Q35891952-F228CE51-9A48-4B52-9D89-D1EB02238F83

P50

Q35891952-FE31F0CA-88A1-4DC7-8AF2-5E7827F6C782

P577

Q35891952-0365ACFE-7DE4-41E6-94D7-6C6EFA976796

P698

Q35891952-1AD87309-05D9-4003-B521-F919CB89A064

P921

Q35891952-0DE30C99-81A9-4E97-A826-977D1FAC2812

P932

Q35891952-DBBC5043-99F8-42DA-BF04-D8C10506A597

P356

SCITRANSLMED.3006103

P1433

Science Translational Medicine

P1476

Plasmid-encoded proinsulin pre ...... 8⁺ T cells in type 1 diabetes.

@en

P2093

BHT-3021 Investigators

http://www.w3.org/2001/XMLSchema#string

Bart O Roep

http://www.w3.org/2001/XMLSchema#string

George S Eisenbarth

http://www.w3.org/2001/XMLSchema#string

Hideki Garren

http://www.w3.org/2001/XMLSchema#string

Joana R F Abreu

http://www.w3.org/2001/XMLSchema#string

Joanne Quan

http://www.w3.org/2001/XMLSchema#string

Lawrence Steinman

http://www.w3.org/2001/XMLSchema#string

Leonard C Harrison

http://www.w3.org/2001/XMLSchema#string

Liping Yu

http://www.w3.org/2001/XMLSchema#string

Matthias von Herrath

http://www.w3.org/2001/XMLSchema#string

P2860

Phenotypic analysis of antigen-specific T lymphocytes

DNA immunization to prevent autoimmune diabetes.

Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers.

Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.

Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.

The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cure.

Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

Preexisting autoantibodies predict efficacy of oral insulin to cure autoimmune diabetes in combination with anti-CD3.

Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetes

P304

191ra82

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1126/SCITRANSLMED.3006103

http://www.w3.org/2001/XMLSchema#string

P407

P433

191

http://www.w3.org/2001/XMLSchema#string

P478

5

http://www.w3.org/2001/XMLSchema#string

P50

P577

2013-06-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

23803704

http://www.w3.org/2001/XMLSchema#string

P921

type-1 diabetes

P932

4516024

http://www.w3.org/2001/XMLSchema#string