Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes.
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Beta cell antigens in type 1 diabetes: triggers in pathogenesis and therapeutic targetsAnti-Insulin Immune Responses Are Detectable in Dogs with Spontaneous DiabetesConcise Review: Cell-Based Therapies and Other Non-Traditional Approaches for Type 1 DiabetesRestoring immune tolerance in neuromyelitis optica: Part IRestoring the balance: immunotherapeutic combinations for autoimmune diseaseCombination therapy with an anti-IL-1β antibody and GAD65 DNA vaccine can reverse recent-onset diabetes in the RIP-GP mouse model.Progress and prospects of gene therapy clinical trials for the muscular dystrophies.Chemical tools to monitor and manipulate the adaptive immune system.Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97.Gene Therapy for Duchenne muscular dystrophy.Present and Future Therapies in Neuromyelitis Optica Spectrum DisordersImmune interventions to preserve β cell function in type 1 diabetesProfile of Lawrence Steinman.Clinical optimization of antigen specific modulation of type 1 diabetes with the plasmid DNA platform.Identification of Candidate Tolerogenic CD8(+) T Cell Epitopes for Therapy of Type 1 Diabetes in the NOD Mouse Model.Non-antigenic and antigenic interventions in type 1 diabetesStrategies for clinical trials in type 1 diabetesExploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccinationA Journey in Science: The Privilege of Exploring the Brain and the Immune System.Efficient Presentation of Multiple Endogenous Epitopes to Both CD4+ and CD8+ Diabetogenic T Cells for ToleranceProgramming of neuroendocrine self in the thymus and its defect in the development of neuroendocrine autoimmunity.Antigen-specific tolerization approaches in multiple sclerosis.The IL-2/IL-2R system: from basic science to therapeutic applications to enhance immune regulation.Treatment of new onset type 1 diabetes with teplizumab: successes and pitfalls in development.Metabolic syndrome - Removing roadblocks to therapy: Antigenic immunotherapiesDevelopment of therapies for autoimmune disease at Stanford: a tale of multiple shots and one goal.Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens.Biomarkers for antigen immunotherapy in allergy and type 1 diabetes.Addressing Unmet Medical Needs in Type 1 Diabetes: A Review of Drugs under Development.A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells.Antigen-specific immunotherapies in rheumatic diseases.Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2.Insulin B chain 9-23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs.Memory of tolerance and induction of regulatory T cells by erythrocyte-targeted antigensImmunological Balance Is Associated with Clinical Outcome after Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes.T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes.Have we pushed the needle for treatment of Type 1 diabetes?Immunotherapy: Modified proinsulin to treat T1DM.Pathophysiological characteristics of preproinsulin-specific CD8+ T cells in subjects with juvenile-onset and adult-onset type 1 diabetes: A 1-year follow-up study.APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice.
P2860
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P2860
Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Plasmid-encoded proinsulin pre ...... 8⁺ T cells in type 1 diabetes.
@ast
Plasmid-encoded proinsulin pre ...... 8⁺ T cells in type 1 diabetes.
@en
type
label
Plasmid-encoded proinsulin pre ...... 8⁺ T cells in type 1 diabetes.
@ast
Plasmid-encoded proinsulin pre ...... 8⁺ T cells in type 1 diabetes.
@en
prefLabel
Plasmid-encoded proinsulin pre ...... 8⁺ T cells in type 1 diabetes.
@ast
Plasmid-encoded proinsulin pre ...... 8⁺ T cells in type 1 diabetes.
@en
P2093
P2860
P1476
Plasmid-encoded proinsulin pre ...... 8⁺ T cells in type 1 diabetes.
@en
P2093
BHT-3021 Investigators
Bart O Roep
George S Eisenbarth
Hideki Garren
Joana R F Abreu
Joanne Quan
Lawrence Steinman
Leonard C Harrison
Matthias von Herrath
P2860
P304
P356
10.1126/SCITRANSLMED.3006103
P407
P50
P577
2013-06-01T00:00:00Z