A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis.

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Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis Mycobacterium tuberculosis in the Face of Host-Imposed Nutrient Limitation.

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Q28553792-078D0BFC-8363-412F-A890-2A7159CF3315 Q39361724-AD377180-9DF0-436A-AF86-ABCEBCEBDD57

P2860

A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis.

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http://www.wikidata.org/entity/Q35894966

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2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis.

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A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis.

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A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis.

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A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis.

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A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis.

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A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis.

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A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis.

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Ana Guardia

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Anuradha Kumar

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David Calvo

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David R Sherman

http://www.w3.org/2001/XMLSchema#string

Elena Jiménez

http://www.w3.org/2001/XMLSchema#string

Esther Pérez

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Fátima Ortega

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Joaquín Rullás

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Raquel C Gabarro

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Ruben M Gómez

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P2860

Thousands of chemical starting points for antimalarial lead identification

Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs

Mycobacterium tuberculosis dihydrofolate reductase reveals two conformational states and a possible low affinity mechanism to antifolate drugs

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

High-throughput screening and sensitized bacteria identify an M. tuberculosis dihydrofolate reductase inhibitor with whole cell activity

Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis

A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis

Ligand efficiency: a useful metric for lead selection

High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening.

P304

604-614

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scholarly article

P356

10.1021/ACSINFECDIS.5B00063

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P478

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Gonzalo Colmenarejo

Lluís Ballell

Pedro Torres

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2015-08-02T00:00:00Z

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26771003

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P921

Mycobacterium tuberculosis

P932

4707675

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A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis.

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P2860

P2860

A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis.

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P2093

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