SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection.
about
Emerging concepts in the immunopathogenesis of AIDSHTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: implications for progression to neurological complicationsRole of PD-1 in HIV pathogenesis and as target for therapyHIV therapeutic vaccines: moving towards a functional cureTIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV InfectionA tonsillar PolyICLC/AT-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessationRe-evaluation of PD-1 expression by T cells as a marker for immune exhaustion during SIV infectionSynergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 BlockadeHigh-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infectionStructure and Interactions of the Human Programmed Cell Death 1 ReceptorLong-term programming of antigen-specific immunity from gene expression signatures in the PBMC of rhesus macaques immunized with an SIV DNA vaccineProgrammed Death-1 expression on Epstein Barr virus specific CD8+ T cells varies by stage of infection, epitope specificity, and T-cell receptor usageAntigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cellsProspects for treatment of latent HIV.Cycling memory CD4+ T cells in HIV disease have a diverse T cell receptor repertoire and a phenotype consistent with bystander activation.Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustionCD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells.Vaccine-induced myeloid cell population dampens protective immunity to SIVDifferential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infectionChronic antigen stimulation alone is sufficient to drive CD8+ T cell exhaustionHIV-induced T-cell activation/exhaustion in rectal mucosa is controlled only partially by antiretroviral treatmentUpregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients.Tularemia vaccines: recent developments and remaining hurdles.Comparison of influenza and SIV specific CD8 T cell responses in macaquesProgrammed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load.Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques.Distinct effector memory CD4+ T cell signatures in latent Mycobacterium tuberculosis infection, BCG vaccination and clinically resolved tuberculosis.Animal models for viral infection and cell exhaustion.Immunization with different viral antigens alters the pattern of T cell exhaustion and latency in herpes simplex virus type 1-infected mice.Diminished viral control during simian immunodeficiency virus infection is associated with aberrant PD-1hi CD4 T cell enrichment in the lymphoid follicles of the rectal mucosa.Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques.Programmed death-1 expression on CD4⁺ and CD8⁺ T cells in treated and untreated HIV disease.CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction.Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic optionsExpansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaquesSoluble PD-1 rescues the proliferative response of simian immunodeficiency virus-specific CD4 and CD8 T cells during chronic infection.Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infectionEnhancing SIV-specific immunity in vivo by PD-1 blockade.Dendritic cell control of tolerogenic responses.
P2860
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P2860
SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
SIV-specific CD8+ T cells expr ...... d chronic SIVmac251 infection.
@ast
SIV-specific CD8+ T cells expr ...... d chronic SIVmac251 infection.
@en
type
label
SIV-specific CD8+ T cells expr ...... d chronic SIVmac251 infection.
@ast
SIV-specific CD8+ T cells expr ...... d chronic SIVmac251 infection.
@en
prefLabel
SIV-specific CD8+ T cells expr ...... d chronic SIVmac251 infection.
@ast
SIV-specific CD8+ T cells expr ...... d chronic SIVmac251 infection.
@en
P2093
P2860
P50
P1433
P1476
SIV-specific CD8+ T cells expr ...... d chronic SIVmac251 infection.
@en
P2093
Constantinos Petrovas
Daniel C Douek
David R Ambrozak
Elzbieta Tryniszewska
Emma Gostick
Genoveffa Franchini
Mario Roederer
Monica Vaccari
Richard A Koup
Sara H Morgan
P2860
P304
P356
10.1182/BLOOD-2007-01-069112
P407
P577
2007-04-17T00:00:00Z