Manganese porphyrin, MnTE-2-PyP5+, Acts as a pro-oxidant to potentiate glucocorticoid-induced apoptosis in lymphoma cells.
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SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathwaysMn porphyrin-based SOD mimic, MnTnHex-2-PyP(5+), and non-SOD mimic, MnTBAP(3-), suppressed rat spinal cord ischemia/reperfusion injury via NF-κB pathwaysData in the activities of caspases and the levels of reactive oxygen species and cytochrome c in the •OH-induced fish erythrocytes treated with alanine, citrulline, proline and their combinationCNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5.MnTE-2-PyP reduces prostate cancer growth and metastasis by suppressing p300 activity and p300/HIF-1/CREB binding to the promoter region of the PAI-1 gene.Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents.Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimicsAn educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways.Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+.Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death.Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells.Anticancer therapeutic potential of Mn porphyrin/ascorbate systemCytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate.Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme.MnTnBuOE-2-PyP protects normal colorectal fibroblasts from radiation damage and simultaneously enhances radio/chemotherapeutic killing of colorectal cancer cellsCompartmentalized oxidative stress in dopaminergic cell death induced by pesticides and complex I inhibitors: distinct roles of superoxide anion and superoxide dismutases.Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cellsRobust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+).Redox dynamics of manganese as a mitochondrial life-death switch.Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.Mitochondria and redox homoeostasis as chemotherapeutic targets.Therapeutic potential of peroxynitrite decomposition catalysts: a patent review.Catalytic antioxidant therapy by metallodrugs: lessons from metallocorroles.MnTE-2-PyP Treatment, or NOX4 Inhibition, Protects against Radiation-Induced Damage in Mouse Primary Prostate Fibroblasts by Inhibiting the TGF-Beta 1 Signaling Pathway.Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeuticsMnTE-2-PyP modulates thiol oxidation in a hydrogen peroxide-mediated manner in a human prostate cancer cell.A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics.Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications.Detailed mechanism of the autoxidation of N-hydroxyurea catalyzed by a superoxide dismutase mimic Mn(III) porphyrin: formation of the nitrosylated Mn(II) porphyrin as an intermediate.Complex chemistry and biology of redox-active compounds, commonly known as SOD mimics, affect their therapeutic effects.Acid-base and electrochemical properties of manganese meso(ortho- and meta-N-ethylpyridyl)porphyrins: voltammetric and chronocoulometric study of protolytic and redox equilibria.Potential Therapeutic Applications of MnSODs and SOD-Mimetics.MnTM-4-PyP modulates endogenous antioxidant responses and protects primary cortical neurons against oxidative stress.The Addition of Manganese Porphyrins during Radiation Inhibits Prostate Cancer Growth and Simultaneously Protects Normal Prostate Tissue from Radiation Damage.Radiation-mediated tumor growth inhibition is significantly enhanced with redox-active compounds that cycle with ascorbate.Redox Paradox: A novel approach to therapeutics-resistant cancer.Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation.
P2860
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P2860
Manganese porphyrin, MnTE-2-PyP5+, Acts as a pro-oxidant to potentiate glucocorticoid-induced apoptosis in lymphoma cells.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Manganese porphyrin, MnTE-2-Py ...... d apoptosis in lymphoma cells.
@ast
Manganese porphyrin, MnTE-2-Py ...... d apoptosis in lymphoma cells.
@en
type
label
Manganese porphyrin, MnTE-2-Py ...... d apoptosis in lymphoma cells.
@ast
Manganese porphyrin, MnTE-2-Py ...... d apoptosis in lymphoma cells.
@en
prefLabel
Manganese porphyrin, MnTE-2-Py ...... d apoptosis in lymphoma cells.
@ast
Manganese porphyrin, MnTE-2-Py ...... d apoptosis in lymphoma cells.
@en
P2093
P2860
P1476
Manganese porphyrin, MnTE-2-Py ...... d apoptosis in lymphoma cells.
@en
P2093
Ines Batinic-Haberle
James D Crapo
Margaret E Tome
Margaret M Briehl
Melba C Jaramillo
P2860
P304
P356
10.1016/J.FREERADBIOMED.2012.02.001
P577
2012-02-11T00:00:00Z