Potential of 4'-C-substituted nucleosides for the treatment of HIV-1.
about
4'-C-methyl-2'-deoxyadenosine and 4'-C-ethyl-2'-deoxyadenosine inhibit HIV-1 replicationIntracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog.Synthesis of 4'-Ethynyl-2'-deoxy-4'-thioribonucleosides and Discovery of a Highly Potent and Less Toxic NRTI.A review of methods to synthesise 4'-substituted nucleosides.4'-Ethynylstavudine (4'-Ed4T) has potent anti-HIV-1 activity with reduced toxicity and shows a unique activity profile against drug-resistant mutants.HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions.Development of modified nucleosides that have supremely high anti-HIV activity and low toxicity and prevent the emergence of resistant HIV mutants.
P2860
Q34933164-B87236F3-190E-48E0-8987-439B82918F5CQ36295462-F638EE67-F2F7-424C-B427-8BACB355EFFFQ36940187-300FFB0F-9724-4E4E-B8E4-5C78419A00A3Q38258804-473F7D55-A3D3-4980-BD87-00173E74EFE0Q40380037-7C4AC513-5C24-48B9-9312-902FDCDEBB0AQ41879018-91B8E00B-70C3-45AE-A678-CAFFA2FA354EQ42104244-02C94D20-FBB2-4B7A-B5F4-018952D0A36F
P2860
Potential of 4'-C-substituted nucleosides for the treatment of HIV-1.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Potential of 4'-C-substituted nucleosides for the treatment of HIV-1.
@ast
Potential of 4'-C-substituted nucleosides for the treatment of HIV-1.
@en
type
label
Potential of 4'-C-substituted nucleosides for the treatment of HIV-1.
@ast
Potential of 4'-C-substituted nucleosides for the treatment of HIV-1.
@en
prefLabel
Potential of 4'-C-substituted nucleosides for the treatment of HIV-1.
@ast
Potential of 4'-C-substituted nucleosides for the treatment of HIV-1.
@en
P2093
P2860
P1476
Potential of 4'-C-substituted nucleosides for the treatment of HIV-1.
@en
P2093
Eiichi Kodama
Hiroaki Mitsuya
Hiroshi Ohrui
Hiroyuki Hayakawa
Kenji Kitano
Noriyuki Ashida
Satoru Kohgo
P2860
P304
P356
10.1177/095632020401500401
P577
2004-07-01T00:00:00Z