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Transgenic studies with a keratin promoter-driven growth hormone transgene: prospects for gene therapy

Transgenic studies with a keratin promoter-driven growth hormone transgene: prospects for gene therapy

http://www.wikidata.org/entity/Q35906330

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Adenomatous polyposis coli (APC) is required for normal development of skin and thymus TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1 Mammalian Merkel cells are descended from the epidermal lineage The POU domain factor Skin-1a represses the keratin 14 promoter independent of DNA binding. A possible role for interactions between Skn-1a and CREB-binding protein/p300 Forced expression of keratin 16 alters the adhesion, differentiation, and migration of mouse skin keratinocytes Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia.Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation.Gene therapy and dermatology: more than just skin deep.Conditional activin receptor type 1B (Acvr1b) knockout mice reveal hair loss abnormality.Ectopic Cdx2 expression in murine esophagus models an intermediate stage in the emergence of Barrett's esophagus.The production and applications of genetically modified skin cells.Defining the regulatory factors required for epidermal gene expression.The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation Advances in skin gene therapy.Cutaneous gene transfer and therapy: the present and the future.Interleukin-8 reduces post-surgical lymphedema formation by promoting lymphatic vessel regeneration.MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis.Stem cells of the skin epithelium.Ameloblastin inhibits cranial suture closure by modulating MSX2 expression and proliferation Cutaneous gene transfer for skin and systemic diseases.Topical gene electrotransfer to the epidermis of hairless guinea pig by non-invasive multielectrode array.The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin.DDB1 is essential for genomic stability in developing epidermis.Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance.Mechanosensory and ATP Release Deficits following Keratin14-Cre-Mediated TRPA1 Deletion Despite Absence of TRPA1 in Murine Keratinocytes Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR A developmental conundrum: a stabilized form of beta-catenin lacking the transcriptional activation domain triggers features of hair cell fate in epidermal cells and epidermal cell fate in hair follicle cells.α-Catulin marks the invasion front of squamous cell carcinoma and is important for tumor cell metastasis.Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion.αE-catenin inhibits a Src-YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway.Gene therapy approaches for stem cell protection.Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death.Smad4 loss in mouse keratinocytes leads to increased susceptibility to UV carcinogenesis with reduced Ercc1-mediated DNA repair Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin A non-surgical approach for male germ cell mediated gene transmission through transgenesis Transcriptional IL-15-directed in vivo DC targeting DNA vaccine.Long-range comparison of human and mouse Sprr loci to identify conserved noncoding sequences involved in coordinate regulation.TGFβ signaling in head and neck squamous cell carcinoma.

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P2860

Transgenic studies with a keratin promoter-driven growth hormone transgene: prospects for gene therapy

http://www.wikidata.org/entity/Q35906330

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1997 nî lūn-bûn

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1997年の論文

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1997年学术文章

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1997年学术文章

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1997年学术文章

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1997年学术文章

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1997年学术文章

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1997年學術文章

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1997年學術文章

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1997年學術文章

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Transgenic studies with a kera ...... ne: prospects for gene therapy

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Transgenic studies with a kera ...... ne: prospects for gene therapy

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Transgenic studies with a kera ...... ne: prospects for gene therapy

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Proceedings of the National Academy of Sciences of the United States of America

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Transgenic studies with a kera ...... ne: prospects for gene therapy

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E Fuchs

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K Polonsky

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X Wang

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P2860

Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control

The expression of mutant epidermal keratin cDNAs transfected in simple epithelial and squamous cell carcinoma lines

The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells

Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells

Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice

Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements.

Calcium regulation of growth and differentiation of mouse epidermal cells in culture.

Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes.

Systemic distribution of apolipoprotein E secreted by grafts of epidermal keratinocytes: implications for epidermal function and gene therapy.

Myoblasts in pattern formation and gene therapy.

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