Human immunodeficiency virus type 1 reverse transcriptase: role of Tyr115 in deoxynucleotide binding and misinsertion fidelity of DNA synthesis
about
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acidsResponse of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivityDetecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment ScreeningReplication defect of moloney murine leukemia virus with a mutant reverse transcriptase that can incorporate ribonucleotides and deoxyribonucleotides.Role of murine leukemia virus reverse transcriptase deoxyribonucleoside triphosphate-binding site in retroviral replication and in vivo fidelity.Effects of amino acid substitutions at position 115 on the fidelity of human immunodeficiency virus type 1 reverse transcriptaseStructure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug designThe N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine.Analysis of mutations at positions 115 and 116 in the dNTP binding site of HIV-1 reverse transcriptase.Human immunodeficiency virus reverse transcriptase: 25 years of research, drug discovery, and promise.Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors".Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA.Mutation rates and intrinsic fidelity of retroviral reverse transcriptases.dNTP versus NTP discrimination by phenylalanine 451 in duck hepatitis B virus P protein indicates a common structure of the dNTP-binding pocket with other reverse transcriptases.A mutation in the primer grip region of HIV-1 reverse transcriptase that confers reduced fidelity of DNA synthesisSecond-site reversion of a human immunodeficiency virus type 1 reverse transcriptase mutant that restores enzyme function and replication capacity.Altering the intracellular environment increases the frequency of tandem repeat deletion during Moloney murine leukemia virus reverse transcription.Mispair extension fidelity of human immunodeficiency virus type 1 reverse transcriptases with amino acid substitutions affecting Tyr115.Increased polymerase fidelity of the 3TC-resistant variants of HIV-1 reverse transcriptase.Deoxyribonucleotide-containing RNAs: a novel class of templates for HIV-1 reverse transcriptase.Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase.Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance.Increased G-->A transition frequencies displayed by primer grip mutants of human immunodeficiency virus type 1 reverse transcriptaseInterrelationship between HIV-1 fitness and mutation rate.Rapid incorporation kinetics and improved fidelity of a novel class of 3'-OH unblocked reversible terminators.Expression and site-directed mutagenesis of the lactococcal abortive phage infection protein AbiK.Nucleotide specificity of HIV-1 reverse transcriptases with amino acid substitutions affecting Ala-114.The impact of molecular manipulation in residue 114 of human immunodeficiency virus type-1 reverse transcriptase on dNTP substrate binding and viral replication.The role of phenylalanine-119 of the reverse transcriptase of mouse mammary tumour virus in DNA synthesis, ribose selection and drug resistance.The cost of replication fidelity in human immunodeficiency virus type 1.
P2860
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P2860
Human immunodeficiency virus type 1 reverse transcriptase: role of Tyr115 in deoxynucleotide binding and misinsertion fidelity of DNA synthesis
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Human immunodeficiency virus t ...... tion fidelity of DNA synthesis
@ast
Human immunodeficiency virus t ...... tion fidelity of DNA synthesis
@en
type
label
Human immunodeficiency virus t ...... tion fidelity of DNA synthesis
@ast
Human immunodeficiency virus t ...... tion fidelity of DNA synthesis
@en
prefLabel
Human immunodeficiency virus t ...... tion fidelity of DNA synthesis
@ast
Human immunodeficiency virus t ...... tion fidelity of DNA synthesis
@en
P2093
P2860
P1433
P1476
Human immunodeficiency virus t ...... tion fidelity of DNA synthesis
@en
P2093
Martín-Hernández AM
Menéndez-Arias L
P2860
P304
P407
P577
1996-08-01T00:00:00Z