Increased polymerase fidelity of the 3TC-resistant variants of HIV-1 reverse transcriptase.
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Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirusStructural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybridMutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication.Increased misincorporation fidelity observed for nucleoside analog resistance mutations M184V and E89G in human immunodeficiency virus type 1 reverse transcriptase does not correlate with the overall error rate measured in vitroThe impact of multidideoxynucleoside resistance-conferring mutations in human immunodeficiency virus type 1 reverse transcriptase on polymerase fidelity and error specificityDevelopment of an in vivo assay to identify structural determinants in murine leukemia virus reverse transcriptase important for fidelityThe P236L delavirdine-resistant human immunodeficiency virus type 1 mutant is replication defective and demonstrates alterations in both RNA 5'-end- and DNA 3'-end-directed RNase H activitiesGenotypic testing for human immunodeficiency virus type 1 drug resistance.Resistance of hepatitis B virus to antiviral drugs: current aspects and directions for future investigation.The M184V mutation in reverse transcriptase can delay reversion of attenuated variants of simian immunodeficiency virus.Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine.Higher fidelity of RNA-dependent DNA mispair extension by M184V drug-resistant than wild-type reverse transcriptase of human immunodeficiency virus type 1.The influence of 3TC resistance mutation M184I on the fidelity and error specificity of human immunodeficiency virus type 1 reverse transcriptase.Mutations proximal to the minor groove-binding track of human immunodeficiency virus type 1 reverse transcriptase differentially affect utilization of RNA versus DNA as template.Mutation V111I in HIV-2 reverse transcriptase increases the fitness of the nucleoside analogue-resistant K65R and Q151M viruses.Molecular impact of the M184V mutation in human immunodeficiency virus type 1 reverse transcriptase.Site-directed mutagenesis in the fingers subdomain of HIV-1 reverse transcriptase reveals a specific role for the beta3-beta4 hairpin loop in dNTP selection.Understanding HIV resistance, fitness, replication capacity and compensation: targeting viral fitness as a therapeutic strategy.Reduced dNTP binding affinity of 3TC-resistant M184I HIV-1 reverse transcriptase variants responsible for viral infection failure in macrophageComparison of G-to-A mutation frequencies induced by APOBEC3 proteins in H9 cells and peripheral blood mononuclear cells in the context of impaired processivities of drug-resistant human immunodeficiency virus type 1 reverse transcriptase variants.The Genetic Basis of HIV-1 Resistance to Reverse Transcriptase and Protease Inhibitors.Mutation rates and intrinsic fidelity of retroviral reverse transcriptases.The high cost of fidelity.New human immunodeficiency virus, type 1 reverse transcriptase (HIV-1 RT) mutants with increased fidelity of DNA synthesis. Accuracy, template binding, and processivity.The M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1 impairs rescue of chain-terminated DNA synthesis.The processivity of DNA synthesis exhibited by drug-resistant variants of human immunodeficiency virus type-1 reverse transcriptase.Limiting deoxynucleoside triphosphate concentrations emphasize the processivity defect of lamivudine-resistant variants of human immunodeficiency virus type 1 reverse transcriptaseDiminished RNA primer usage associated with the L74V and M184V mutations in the reverse transcriptase of human immunodeficiency virus type 1 provides a possible mechanism for diminished viral replication capacity.Quantification of the effects on viral DNA synthesis of reverse transcriptase mutations conferring human immunodeficiency virus type 1 resistance to nucleoside analogues.Correlation of recombinant integrase activity and functional preintegration complex formation during acute infection by replication-defective integrase mutant human immunodeficiency virus.AZT resistance alters enzymatic properties and creates an ATP-binding site in SFVmac reverse transcriptase.Substitutions of Phe61 located in the vicinity of template 5'-overhang influence polymerase fidelity and nucleoside analog sensitivity of HIV-1 reverse transcriptase.Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations.Thermostable HIV-1 group O reverse transcriptase variants with the same fidelity as murine leukaemia virus reverse transcriptase.Structural determinants of slippage-mediated mutations by human immunodeficiency virus type 1 reverse transcriptase.The processivity and fidelity of DNA synthesis exhibited by the reverse transcriptase of bovine leukemia virus.Polymerase-dependent DNA synthesis from phosphoramidate-activated nucleotides.Dominance of the E89G substitution in HIV-1 reverse transcriptase in regard to increased polymerase processivity and patterns of pausing.
P2860
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P2860
Increased polymerase fidelity of the 3TC-resistant variants of HIV-1 reverse transcriptase.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Increased polymerase fidelity ...... f HIV-1 reverse transcriptase.
@en
Increased polymerase fidelity ...... f HIV-1 reverse transcriptase.
@nl
type
label
Increased polymerase fidelity ...... f HIV-1 reverse transcriptase.
@en
Increased polymerase fidelity ...... f HIV-1 reverse transcriptase.
@nl
prefLabel
Increased polymerase fidelity ...... f HIV-1 reverse transcriptase.
@en
Increased polymerase fidelity ...... f HIV-1 reverse transcriptase.
@nl
P2093
P2860
P356
P1476
Increased polymerase fidelity ...... f HIV-1 reverse transcriptase.
@en
P2093
Berkhout B
Oude Essink BB
P2860
P304
P356
10.1093/NAR/25.16.3212
P407
P577
1997-08-01T00:00:00Z