Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice
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Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectivesWhy Is there a Limit to the Changes in Myofilament Ca2+-Sensitivity Associated with Myopathy Causing Mutations?Molecular mechanisms of cardiomyopathy phenotypes associated with myosin light chain mutationsN-Terminus of Cardiac Myosin Essential Light Chain Modulates Myosin Step-Size.Myosin light chain phosphorylation to the rescue.A Novel Method of Determining the Functional Effects of a Minor Genetic Modification of a Protein.Proteomic analysis of physiological versus pathological cardiac remodeling in animal models expressing mutations in myosin essential light chains.Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities.Revisiting Frank-Starling: regulatory light chain phosphorylation alters the rate of force redevelopment (ktr ) in a length-dependent fashionGene expression patterns in transgenic mouse models of hypertrophic cardiomyopathy caused by mutations in myosin regulatory light chain.Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice.Transmural gradients of myocardial structure and mechanics: Implications for fiber stress and strain in pressure overload.Pseudophosphorylation of cardiac myosin regulatory light chain: a promising new tool for treatment of cardiomyopathy.Top-Down Targeted Proteomics Reveals Decrease in Myosin Regulatory Light-Chain Phosphorylation That Contributes to Sarcopenic Muscle Dysfunction.Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes.Molecular and Functional Effects of a Splice Site Mutation in the MYL2 Gene Associated with Cardioskeletal Myopathy and Early Cardiac Death in Infants.Myosin light chain phosphorylation, novel targets to repair a broken heart?Altered myofilament structure and function in dogs with Duchenne muscular dystrophy cardiomyopathy.Cardiac contractility, motor function, and cross-bridge kinetics in N47K-RLC mutant mice.Cardiac myofibrillar contractile properties during the progression from hypertension to decompensated heart failure.Distinct sequences and post-translational modifications in cardiac atrial and ventricular myosin light chains revealed by top-down mass spectrometry.Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice.Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle.Essential light chain S195 phosphorylation is required for cardiac adaptation under physical stress.
P2860
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P2860
Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice
description
2015 nî lūn-bûn
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2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
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2015年论文
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name
Constitutive phosphorylation o ...... trophic cardiomyopathy in mice
@ast
Constitutive phosphorylation o ...... trophic cardiomyopathy in mice
@en
type
label
Constitutive phosphorylation o ...... trophic cardiomyopathy in mice
@ast
Constitutive phosphorylation o ...... trophic cardiomyopathy in mice
@en
prefLabel
Constitutive phosphorylation o ...... trophic cardiomyopathy in mice
@ast
Constitutive phosphorylation o ...... trophic cardiomyopathy in mice
@en
P2093
P2860
P356
P1476
Constitutive phosphorylation o ...... trophic cardiomyopathy in mice
@en
P2093
Chen-Ching Yuan
Danuta Szczesna-Cordary
Jingsheng Liang
Joshua M Hare
Katarzyna Kazmierczak
Priya Muthu
Thomas C Irving
Wenrui Huang
P2860
P304
P356
10.1073/PNAS.1505819112
P407
P577
2015-06-29T00:00:00Z