Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice.
about
Channelopathies from mutations in the cardiac sodium channel protein complexNa+ channel function, regulation, structure, trafficking and sequestrationUltrastructure of the intercellular space in adult murine ventricle revealed by quantitative tomographic electron microscopyIonic mechanisms of arrhythmogenesisIon channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac deathSodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency.Intercalated disc abnormalities, reduced Na(+) current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changesPost-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmiasSuper-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaqueCx43 phosphorylation on S279/282 and intercellular communication are regulated by IP3/IP3 receptor signalingMicrodomain-specific localization of functional ion channels in cardiomyocytes: an emerging concept of local regulation and remodelling.Cx43 associates with Na(v)1.5 in the cardiomyocyte perinexus.Age-associated alterations of cardiac structure and function in the female F344xBN rat heart.Toward panoramic in situ mapping of action potential propagation in transgenic hearts to investigate initiation and therapeutic control of arrhythmias.Mechanisms of cardiac conduction: a history of revisions.Diseases caused by mutations in Nav1.5 interacting proteinsSuper-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc.Assembly of the cardiac intercalated disk during pre- and postnatal development of the human heart.Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias.Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current.Sodium channels in the Cx43 gap junction perinexus may constitute a cardiac ephapse: an experimental and modeling study.Selective Connexin43 Inhibition Prevents Isoproterenol-Induced Arrhythmias and Lethality in Muscular Dystrophy Mice.Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43Slow conduction in mixed cultured strands of primary ventricular cells and stem cell-derived cardiomyocytes.Spatial Heterogeneity of Cx43 is an Arrhythmogenic Substrate of Polymorphic Ventricular Tachycardias during Compensated Cardiac Hypertrophy in Rats.The cardiac connexome: Non-canonical functions of connexin43 and their role in cardiac arrhythmias.Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.Islands of spatially discordant APD alternans underlie arrhythmogenesis by promoting electrotonic dyssynchrony in models of fibrotic rat ventricular myocardium.New protein-protein interactions of mitochondrial connexin 43 in mouse heartDeletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels.Connexin diversity in the heart: insights from transgenic mouse models.Identification of rare variants of DSP gene in sudden unexplained nocturnal death syndrome in the southern Chinese Han populationIntercellular electrical communication in the heart: a new, active role for the intercalated disk.Involvement of Rictor/mTORC2 in cardiomyocyte differentiation of mouse embryonic stem cells in vitro.Electrotonic suppression of early afterdepolarizations in the neonatal rat ventricular myocyte monolayer.Cardiovascular microRNAs: as modulators and diagnostic biomarkers of diabetic heart disease.Gap-junction-mediated cell-to-cell communication.The perinexus: sign-post on the path to a new model of cardiac conduction?Determinants of myocardial conduction velocity: implications for arrhythmogenesis.Old cogs, new tricks: a scaffolding role for connexin43 and a junctional role for sodium channels?
P2860
Q26824051-B97286BE-7711-43D9-A565-5F74B87FDFE1Q27005721-50AD64C0-F52B-446C-A923-41BAEAEBD661Q27302096-35A64DE9-1A83-433C-81A9-8735C9B0E186Q28080424-FE425C84-7504-424A-AFDB-587BBC5FE69DQ28087459-A58E2F9D-528A-4D93-BFC5-2D962A9CF92BQ28270379-FD06D715-9DB7-46AB-80B0-8F0D94FEAFA7Q28270388-1B41393A-C9D8-48C1-9FC6-A9F8705338D4Q28292930-24255712-2A87-4122-95AC-AD5B5624B672Q28296189-BECBACD1-EB63-46A8-9264-CC0F8B0F5C9EQ30591754-2A88BB4E-617D-4AA1-9EF0-FEC73FC5FBF3Q33659429-0655D925-D576-4F0B-8569-9E3083F35CFEQ33856632-75B3D654-5F0B-4D50-A648-93706797211AQ34116069-EEA641A7-3EDC-4C35-B6E3-2E1B02E035E0Q34148596-A995B691-0577-40F7-B0A2-AB3179203C35Q34397295-6A337295-AB74-430A-9BEF-C9B2F1CB44FCQ34482816-1C8E85F7-8C57-404B-B66D-15A9E2572733Q34974501-2035B570-97E3-4BE5-8CA3-EBD0343E50F5Q35147854-7F6384DA-3E71-400F-965A-0646FA825734Q35242478-F7EFC837-6005-4DB9-9F2C-93EDAC9E5F5AQ35839115-30A45F83-AFD2-4252-8835-D7B00C851D03Q35847180-BB3B8584-B311-487F-A7A0-992D89BCB826Q35999445-5846773B-6223-49EB-92E7-1D417F702007Q36054423-B50ACA0C-88E5-432B-BF6E-94A0EF54ACE2Q36098333-C5C506C3-92B4-4FD9-9761-46E87A813EE2Q36637706-1A2D38D2-79C3-450C-A27E-B469B078D00FQ36654881-C909E4FE-8E0D-4C03-AADA-CFF58A50136AQ36716425-FAB47A28-619D-460C-9450-49A524F59C40Q36793175-15FE400A-4D51-4ED6-95FD-8A3246269706Q36797515-6E403D3D-17C7-4F36-B14F-9099460744E9Q36919661-8D54282B-C1BC-4F24-9F8E-69CDDA31BAB1Q36958996-7C44E18C-FE39-46EA-84FA-7D2A5B14C561Q37109311-D462FDCA-6FF8-49B7-91C5-9EE37156190FQ37488279-B6E6D124-629E-434D-9311-64DE07ACB399Q37604612-13C8D2BE-0B04-4C40-8C5D-CAC58EF49C41Q37606111-AABB78FE-1CE3-49A6-A106-3A73D7A64E73Q37685243-11466647-8F3D-4B5A-BDD3-B9BFD1623B0FQ38039836-68186373-4FD8-457F-AEE1-EB86DFF8C7E5Q38089420-9F359AA6-CA86-465E-A934-EBE42F13226FQ38119213-A718E5B2-04AB-4A40-A5B2-BE8E8A98BD9BQ38184186-0FE85AF3-4FAA-43DB-8867-D083C27E01DE
P2860
Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Reduced heterogeneous expressi ...... onditional Cx43 knockout mice.
@ast
Reduced heterogeneous expressi ...... onditional Cx43 knockout mice.
@en
type
label
Reduced heterogeneous expressi ...... onditional Cx43 knockout mice.
@ast
Reduced heterogeneous expressi ...... onditional Cx43 knockout mice.
@en
prefLabel
Reduced heterogeneous expressi ...... onditional Cx43 knockout mice.
@ast
Reduced heterogeneous expressi ...... onditional Cx43 knockout mice.
@en
P2093
P2860
P1433
P1476
Reduced heterogeneous expressi ...... onditional Cx43 knockout mice.
@en
P2093
Harold V van Rijen
Hassan Musa
Jacques M de Bakker
John A Jansen
Maartje Noorman
Marc A Vos
Mèra Stein
Peter J Mohler
Roel van der Nagel
Sanne de Jong
P2860
P304
P356
10.1016/J.HRTHM.2011.11.025
P50
P577
2011-11-16T00:00:00Z