Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice. - Wikidata - wikimedia - TriplyDB

Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice.

Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice.

http://www.wikidata.org/entity/Q35913146

about

Multiple NSAID-induced hits injure the small intestine: underlying mechanisms and novel strategies Molecular Insights into Microbial -Glucuronidase Inhibition to Abrogate CPT-11 Toxicity Developing a metagenomic view of xenobiotic metabolism Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics.Real-time imaging of intestinal bacterial β-glucuronidase activity by hydrolysis of a fluorescent probe Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics.Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity Microbial determinants of biochemical individuality and their impact on toxicology and pharmacology.The microbiota, chemical symbiosis, and human disease.Evaluation of the effect of blackcurrant products on gut microbiota and on markers of risk for colon cancer in humans.The human microbiome is a source of therapeutic drug targets.Intestinal microbiome and digoxin inactivation: meal plan for digoxin users?Understanding and modulating mammalian-microbial communication for improved human health.NSAID enteropathy and bacteria: a complicated relationship.Review: Mechanisms of How the Intestinal Microbiota Alters the Effects of Drugs and Bile Acids.Unique β-Glucuronidase Locus in Gut Microbiomes of Crohn's Disease Patients and Unaffected First-Degree Relatives The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism The metabolic role of the gut microbiota in health and rheumatic disease: mechanisms and interventions.Role of intestinal cytochrome p450 enzymes in diclofenac-induced toxicity in the small intestine.Targeting of microbe-derived metabolites to improve human health: The next frontier for drug discovery.Glucuronides in the gut: Sugar-driven symbioses between microbe and host.Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics Mechanisms, prevention and clinical implications of nonsteroidal anti-inflammatory drug-enteropathy.An Atlas of β-Glucuronidases in the Human Intestinal Microbiome.Non-cytochrome P450-mediated bioactivation and its toxicological relevance.Gut microbiome interactions with drug metabolism, efficacy, and toxicity.Rebamipide protects small intestinal mucosal injuries caused by indomethacin by modulating intestinal microbiota and the gene expression in intestinal mucosa in a rat model.Ciprofloxacin blocked enterohepatic circulation of diclofenac and alleviated NSAID-induced enteropathy in rats partly by inhibiting intestinal β-glucuronidase activity.Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites.How close are we to developing enteric-protective drugs against non-steroidal anti-inflammatory drug-induced small intestinal injury? New mechanistic insight from preclinical models.Nonsteroidal Anti-Inflammatory Drug-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells.Non-steroidal anti-inflammatory drug-induced enteropathy.Role of enterohepatic recirculation in drug disposition: cooperation and complications.Structural basis for the regulation of β-glucuronidase expression by human gut Enterobacteriaceae.Impact of gut microbiota on drug metabolism: an update for safe and effective use of drugs.The role of gut microbiota in the modulation of drug action: a focus on some clinically significant issues.Immunomodulatory interplay of the microbiome and therapy of rheumatic diseases.Glucuronidation: driving factors and their impact on glucuronide disposition Experimental study of diclofenac and its biliary metabolites on anastomotic healing β-Glucuronidases of opportunistic bacteria are the major contributors to xenobiotic-induced toxicity in the gut

P2860

Q27000132-D4C73DFD-AB82-498D-B524-5B501B2538F2 Q27678202-A382E2F7-B550-449C-8869-26DA26D88B1C Q28273307-F8BBAF02-2AD5-4B31-B82A-EBAE4CA77180 Q33779249-EA08636F-C23B-445A-9E83-BE4E109E9DC3 Q33784710-5C95A373-2709-448B-B096-B914488EBFE1 Q34311685-70B3DDAB-2DBC-409E-A4A1-56EEBB737A02 Q34493889-B69E510D-B0AD-40E6-B512-F15B60420F03 Q34615534-8DE2711F-ED49-4CAF-86CE-BCD92AAEAAA8 Q34616219-04407B02-2F5E-4F99-81F4-FB75811AB0CB Q34722373-D0118FC9-FB7E-46CC-8FE1-788CAD50C562 Q34726528-2936EB6A-13DB-4EB2-9A6D-9DABA402970F Q35012050-B6DBBAAA-3665-41D6-B492-AA77C1F752DE Q35026463-A1D9B78A-CFAD-4FF0-9AED-AB5A99E54BEE Q35540435-71539340-5291-4F4F-B322-9D5A8E355C55 Q35742169-F29CBCC2-265E-4285-B281-0EB9716E827D Q35908239-6D3EE293-8690-47CE-A24A-758395884D6E Q35955534-57A602BB-CEFC-435E-8D84-C75E39705F7D Q36038992-6A213833-3A5E-4710-9F2D-BAAD0CA1AAEA Q36335498-4A9EC8EA-23F6-4FBD-9C21-D8114CC1CF08 Q36340545-099DB786-6644-43C7-8928-A8CC4EDDFACB Q36340552-9B840822-B2FD-4D7C-B336-7CC705AA4554 Q37679135-AD38FC39-246A-48DA-A953-F379FF064493 Q38097424-7065AAB6-8F92-42D9-942D-DCE01379BF06 Q38746100-3828B19C-8836-495D-81F9-D0AF56C66F04 Q38929936-7A7AA20B-72D9-4563-A886-D70C89D54FDE Q38945423-484D12AC-4B8A-47C0-BD7A-D25C7399F705 Q41361724-FF6258D0-D09C-4540-93D6-6DD9E7A06F43 Q41871344-A4B1F39E-8770-4B8B-A625-6D5D075FEC71 Q42705851-28BF35BD-CB00-4EE2-AAFF-1B0EAD2E3996 Q43609300-2CB6C447-B6FF-481C-880D-FB470E3CECED Q44876695-AC38D0F2-07AB-41FF-81A2-CBA4FE9E9DCD Q45400230-4F2C8E8A-15B1-42E3-9490-7D7063C47275 Q46578287-AACEE6B3-5AE7-437F-9C9F-67B52F4592AB Q47263968-A06ADDB5-62C4-428C-AE18-5F6F3BABB66D Q48226113-C035631F-095F-44ED-AEAC-D8358397F4AF Q50054146-5B8FBD60-5E62-48D5-BEE1-84B78A4E20D9 Q50067815-15BE35B5-C4E5-4EDE-9AE5-3A047523871D Q56030213-BF94BAAE-C7CB-4111-913E-F1EB0D4F4DCF Q57119214-7ED0F9C5-4E75-4004-B54C-A7BF782EF19B Q58608842-C4105DAE-A10B-42AC-82E9-E83BE7C513DB

P2860

Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice.

http://www.wikidata.org/entity/Q35913146

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

Pharmacologic targeting of bac ...... g-induced enteropathy in mice.

@ast

Pharmacologic targeting of bac ...... g-induced enteropathy in mice.

@en

type

label

Pharmacologic targeting of bac ...... g-induced enteropathy in mice.

@ast

Pharmacologic targeting of bac ...... g-induced enteropathy in mice.

@en

prefLabel

Pharmacologic targeting of bac ...... g-induced enteropathy in mice.

@ast

Pharmacologic targeting of bac ...... g-induced enteropathy in mice.

@en

P1433

Q35913146-C7F13839-348F-4AC2-96F6-1A6111EEE92B

P1476

Q35913146-E56B36B9-2C50-411D-96D6-E67B5271AFA3

P2093

Q35913146-3150DC3A-8C2B-46E0-A022-B2A8F35386C2

Q35913146-42829814-AE3D-432E-838B-B174444D6F02

Q35913146-72B01D56-5952-4056-BDF4-4891375A4DA3

Q35913146-FD47CED0-7E25-4C8B-9563-D356A356AEB4

P2860

Q35913146-147B4C2D-B96A-4489-9B7E-3EDE12654841

Q35913146-1A02AA06-EA00-4798-A5CA-291CB8EE123C

Q35913146-1D91ACE5-10E1-4C9A-8AD0-EF4BCCA71BB6

Q35913146-3801D45E-FEDF-4B4B-ADED-524DCC0330BB

Q35913146-39AD8502-BC61-4FD2-95A6-E82B2CD30567

Q35913146-486B708E-7AA0-4B23-94D5-3AF5031EFF10

Q35913146-49198F23-B821-4FB5-95B4-10B15E4CC37F

Q35913146-4DC6ABDC-177F-46C8-80B6-3904A8EAED83

Q35913146-5714E6D9-195B-4CD9-8DAA-459D666C6CA9

Q35913146-63CD2F83-BD27-4911-BAFB-C84D505EEE94

P304

Q35913146-36DFC1CB-98C2-485A-B268-A4179A1E33D8

P31

Q35913146-40D38BE3-C413-467B-8697-B1E827ED1444

P356

Q35913146-E4CC5951-8AF4-443D-A71D-969BC0D490FD

P407

Q35913146-206BB7AA-DDE4-43A2-8613-D7599D97B9F2

P433

Q35913146-B5970EBE-3F3D-4681-928D-826A8A013F8B

P478

Q35913146-FD696670-3B04-4149-B75D-65572DC6B45B

P50

Q35913146-12A60A66-7A75-478C-851C-11F00F28CC53

P577

Q35913146-4935A579-C1A5-4825-B134-71E8D6F958B3

P5875

Q35913146-F835C6DA-1CC6-4EBC-A81B-A2D9C3F16B3B

P698

Q35913146-A3E1C5A5-05A1-4082-BB74-375F28F3901F

P921

Q35913146-99D0368E-26F2-4AF9-99AB-117EC28FB5C1

P932

Q35913146-DF2A55EF-9C6C-40A4-861C-34A01DB9482A

P356

JPET.111.191122

P1433

Journal of Pharmacology and Experimental Therapeutics

P1476

Pharmacologic targeting of bac ...... g-induced enteropathy in mice.

@en

P2093

Amanda LoGuidice

http://www.w3.org/2001/XMLSchema#string

Bret D Wallace

http://www.w3.org/2001/XMLSchema#string

Lauren Bendel

http://www.w3.org/2001/XMLSchema#string

Urs A Boelsterli

http://www.w3.org/2001/XMLSchema#string

P2860

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide.

Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs.

Detection and prevention of NSAID-induced enteropathy.

Mechanisms underlying intestinal injury induced by anti-inflammatory COX inhibitors.

Intestinal tract injury by drugs: Importance of metabolite delivery by yellow bile road.

Effect of the beta-glucuronidase inhibitor saccharolactone on glucuronidation by human tissue microsomes and recombinant UDP-glucuronosyltransferases.

Capsule endoscopic diagnosis of nonsteroidal antiinflammatory drug-induced enteropathy.

Acyl glucuronides: the good, the bad and the ugly.

Nonsteroidal antiinflammatory drug-related injury to the gastrointestinal tract: clinical picture, pathogenesis, and prevention.

P304

447-454

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1124/JPET.111.191122

http://www.w3.org/2001/XMLSchema#string

P407

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

341

http://www.w3.org/2001/XMLSchema#string

P50

Matthew R Redinbo

P577

2012-02-10T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

221826906

http://www.w3.org/2001/XMLSchema#string

P698

22328575

http://www.w3.org/2001/XMLSchema#string

P921

P932

3336811

http://www.w3.org/2001/XMLSchema#string