Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIV(SM).
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New insights into an X-traordinary viral proteinSAMHD1-Dependent and -Independent Functions of HIV-2/SIV Vpx ProteinThe human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infectionInteraction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex.Viral protein R regulates nuclear import of the HIV-1 pre-integration complexHIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infectionSAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphatesHuman immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2AVpx is critical for reverse transcription of the human immunodeficiency virus type 2 genome in macrophagesHuman immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repairUracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrestHuman immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustardEarly steps of retrovirus replicative cycleThe Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T CellsSmall heat shock protein suppression of Vpr-induced cytoskeletal defects in budding yeast.Restriction of HIV-1 replication in monocytes is abolished by Vpx of SIVsmmPBjLentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infectionHsp40 facilitates nuclear import of the human immunodeficiency virus type 2 Vpx-mediated preintegration complexPrimate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.Nuclear targeting of the cauliflower mosaic virus coat proteinInteraction with the p6 domain of the gag precursor mediates incorporation into virions of Vpr and Vpx proteins from primate lentivirusesMutational analysis of Vpr-induced G2 arrest, nuclear localization, and cell death in fission yeast.Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytesThe putative alpha helix 2 of human immunodeficiency virus type 1 Vpr contains a determinant which is responsible for the nuclear translocation of proviral DNA in growth-arrested cellsIsolation and characterization of a neuropathogenic simian immunodeficiency virus derived from a sooty mangabey.Interaction of human immunodeficiency virus type 2 Vpx and invariant chain.Isolation of human immunodeficiency virus type 1 cores: retention of Vpr in the absence of p6(gag).Human immunodeficiency virus and AIDS: insights from animal lentivirusesA conserved dileucine-containing motif in p6(gag) governs the particle association of Vpx and Vpr of simian immunodeficiency viruses SIV(mac) and SIV(agm)Functional analysis of the simian immunodeficiency virus Vpx protein: identification of packaging determinants and a novel nuclear targeting domain.HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import.Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase.The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylationSimian immunodeficiency virus Vpx is imported into the nucleus via importin alpha-dependent and -independent pathwaysHIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic interventionVpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon.
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Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIV(SM).
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Nuclear import and cell cycle ...... parate genes in HIV-2/SIV(SM).
@ast
Nuclear import and cell cycle ...... parate genes in HIV-2/SIV(SM).
@en
type
label
Nuclear import and cell cycle ...... parate genes in HIV-2/SIV(SM).
@ast
Nuclear import and cell cycle ...... parate genes in HIV-2/SIV(SM).
@en
prefLabel
Nuclear import and cell cycle ...... parate genes in HIV-2/SIV(SM).
@ast
Nuclear import and cell cycle ...... parate genes in HIV-2/SIV(SM).
@en
P2093
P2860
P1433
P1476
Nuclear import and cell cycle ...... eparate genes in HIV-2/SIV(SM)
@en
P2093
B Brichacek
G Stivahtis
M A Newman
M Stevenson
T M Fletcher
P2860
P304
P356
10.1002/J.1460-2075.1996.TB01003.X
P407
P577
1996-11-01T00:00:00Z