Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection
about
SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infectionNew insights into an X-traordinary viral proteinSAMHD1-Dependent and -Independent Functions of HIV-2/SIV Vpx ProteinThe HIV1 protein Vpr acts to enhance constitutive DCAF1-dependent UNG2 turnoverThe human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infectionHIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasomeSAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by VpxVpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 proteinFormation of mobile chromatin-associated nuclear foci containing HIV-1 Vpr and VPRBP is critical for the induction of G2 cell cycle arrestThe Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T CellsStructural basis of lentiviral subversion of a cellular protein degradation pathwayThe DDB1-DCAF1-Vpr-UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destructionProteomic approaches to uncovering virus-host protein interactions during the progression of viral infectionHepatitis B: progress in understanding chronicity, the innate immune response, and cccDNA protectionDistinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4BCullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complexSAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.Interactions with DCAF1 and DDB1 in the CRL4 E3 ubiquitin ligase are required for Vpr-mediated G2 arrest.Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytesHost hindrance to HIV-1 replication in monocytes and macrophages.HIV-1 Vpr and G2 cell cycle arrest.The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.Nuclear import of SAMHD1 is mediated by a classical karyopherin α/β1 dependent pathway and confers sensitivity to VpxMAC induced ubiquitination and proteasomal degradation.Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.SIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion release.APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylationDevelopment of monoclonal antibodies specifically recognizing the endogenous sterile alpha motif and HD domain 1 protein in porcine cell lines.Hepatitis B virus HBx protein interactions with the ubiquitin proteasome system.The inside out of lentiviral vectorsCyclin L2 is a critical HIV dependency factor in macrophages that controls SAMHD1 abundance.Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1.Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradationHIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic interventionUnderstanding the molecular manipulation of DCAF1 by the lentiviral accessory proteins Vpr and Vpx.Human immunodeficiency virus type 1 modified to package Simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cells.Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon.
P2860
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P2860
Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Lentiviral Vpx accessory facto ...... to enable macrophage infection
@ast
Lentiviral Vpx accessory facto ...... to enable macrophage infection
@en
Lentiviral Vpx accessory facto ...... to enable macrophage infection
@nl
type
label
Lentiviral Vpx accessory facto ...... to enable macrophage infection
@ast
Lentiviral Vpx accessory facto ...... to enable macrophage infection
@en
Lentiviral Vpx accessory facto ...... to enable macrophage infection
@nl
prefLabel
Lentiviral Vpx accessory facto ...... to enable macrophage infection
@ast
Lentiviral Vpx accessory facto ...... to enable macrophage infection
@en
Lentiviral Vpx accessory facto ...... to enable macrophage infection
@nl
P2093
P2860
P50
P3181
P1433
P1476
Lentiviral Vpx accessory facto ...... to enable macrophage infection
@en
P2093
Jacek Skowronski
Selene K Swanson
Smita Srivastava
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1000059
P407
P577
2008-05-09T00:00:00Z