Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis.
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Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking11β-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE⁻/⁻ miceMucosal tolerance to a combination of ApoB and HSP60 peptides controls plaque progression and stabilizes vulnerable plaque in Apob(tm2Sgy)Ldlr(tm1Her)/J miceAccumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transportSignal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo.Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP.The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression.Interaction of functional NPC1 gene polymorphism with smoking on coronary heart diseaseMacrophage death and defective inflammation resolution in atherosclerosis.FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.Class A scavenger receptor activation inhibits endoplasmic reticulum stress-induced autophagy in macrophageThe role of endoplasmic reticulum stress in the progression of atherosclerosis.NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosisA reporter for tracking the UPR in vivo reveals patterns of temporal and cellular stress during atherosclerotic progression.Targeting annexin A7 by a small molecule suppressed the activity of phosphatidylcholine-specific phospholipase C in vascular endothelial cells and inhibited atherosclerosis in apolipoprotein E⁻/⁻micen-3 Fatty acids decrease arterial low-density lipoprotein cholesterol delivery and lipoprotein lipase levels in insulin-resistant miceDiabetes adversely affects macrophages during atherosclerotic plaque regression in mice.Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels.Macrophage autophagy plays a protective role in advanced atherosclerosis.Vessel wall apoptosis and atherosclerotic plaque instability.Thematic review series: The immune system and atherogenesis. Cytokine regulation of macrophage functions in atherogenesis.Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor.Methods and models for monitoring UPR-associated macrophage death during advanced atherosclerosisMacrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in miceLoss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice.Mechanisms and consequences of macrophage apoptosis in atherosclerosis.Brief report: increased apoptosis in advanced atherosclerotic lesions of Apoe-/- mice lacking macrophage Bcl-2.Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways.Macrophage apoptosis in atherosclerosis: consequences on plaque progression and the role of endoplasmic reticulum stressBone marrow deficiency of TRPC3 channel reduces early lesion burden and necrotic core of advanced plaques in a mouse model of atherosclerosis.Sterols and sphingolipids: dynamic duo or partners in crime?Adipose triglyceride lipase in immune response, inflammation, and atherosclerosis.Molecular biology of atherosclerosis.Complement Protein C1q Enhances Macrophage Foam Cell Survival and Efferocytosis.Novel mechanism of U18666A-induced tumour necrosis factor-alpha production in RAW 264.7 macrophage cells.HMG-CoA reductase inhibitors activate the unfolded protein response and induce cytoprotective GRP78 expression.Sitosterol-containing lipoproteins trigger free sterol-induced caspase-independent death in ACAT-competent macrophages.Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and aThe impact of insulin resistance on macrophage death pathways in advanced atherosclerosis.Macrophage apoptosis in advanced atherosclerosis.
P2860
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P2860
Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Niemann-Pick C heterozygosity ...... sis in murine atherosclerosis.
@ast
Niemann-Pick C heterozygosity ...... sis in murine atherosclerosis.
@en
type
label
Niemann-Pick C heterozygosity ...... sis in murine atherosclerosis.
@ast
Niemann-Pick C heterozygosity ...... sis in murine atherosclerosis.
@en
prefLabel
Niemann-Pick C heterozygosity ...... sis in murine atherosclerosis.
@ast
Niemann-Pick C heterozygosity ...... sis in murine atherosclerosis.
@en
P2093
P2860
P356
P1476
Niemann-Pick C heterozygosity ...... sis in murine atherosclerosis.
@en
P2093
Cecillia M Devlin
Dajun Zhang
George Kuriakose
Mark Kockx
P2860
P304
10423-10428
P356
10.1073/PNAS.1732494100
P407
P577
2003-08-15T00:00:00Z