Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways.
about
Kinases as druggable targets in trypanosomatid protozoan parasitesThe final link: tapping the power of chemical genetics to connect the molecular and biologic functions of mitotic protein kinasesA Novel Approach to the Discovery of Small-Molecule Ligands of CDK2Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent KinasesGetting to S: CDK functions and targets on the path to cell-cycle commitmentModulation of plant growth in vivo and identification of kinase substrates using an analog-sensitive variant of CYCLIN-DEPENDENT KINASE A;1MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis.Dysregulation of RNA polymerase I transcription during disease.Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.Identification and Characterization of an Irreversible Inhibitor of CDK2.Cyclin-Dependent Kinase Inhibitors as Anticancer TherapeuticsReinforcing targeted therapeutics with phenotypic stability factorsTaking on challenging targets: making MYC druggable.AMPKα1 deletion in fibroblasts promotes tumorigenesis in athymic nude mice by p52-mediated elevation of erythropoietin and CDK2.System-based drug discovery within the human kinome.Recent progress of cyclin-dependent kinase inhibitors as potential anticancer agents.CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition.Why minimal is not optimal: driving the mammalian cell cycle--and drug discovery--with a physiologic CDK control network.Spatial competition constrains resistance to targeted cancer therapy.Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.
P2860
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P2860
Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways.
description
2012 nî lūn-bûn
@nan
2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
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2012年论文
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2012年论文
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name
Chemical-genetic analysis of c ...... y multiple oncogenic pathways.
@ast
Chemical-genetic analysis of c ...... y multiple oncogenic pathways.
@en
type
label
Chemical-genetic analysis of c ...... y multiple oncogenic pathways.
@ast
Chemical-genetic analysis of c ...... y multiple oncogenic pathways.
@en
prefLabel
Chemical-genetic analysis of c ...... y multiple oncogenic pathways.
@ast
Chemical-genetic analysis of c ...... y multiple oncogenic pathways.
@en
P2093
P2860
P356
P1476
Chemical-genetic analysis of c ...... y multiple oncogenic pathways.
@en
P2093
Andrei Goga
Chao Zhang
Dai Horiuchi
Karl A Merrick
Katelyn J Creasman
Kevan M Shokat
Leonard Kusdra
Noelle E Huskey
Robert P Fisher
P2860
P304
P356
10.1073/PNAS.1111317109
P407
P577
2012-04-03T00:00:00Z