Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo.
about
Identifying the rules of engagement enabling leukocyte rolling, activation, and adhesionDisruption of the integrin alphaLbeta2 transmembrane domain interface by beta2 Thr-686 mutation activates alphaLbeta2 and promotes micro-clustering of the alphaL subunitsBinding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigenDistribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhereCrystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptorSmall Molecule Targeting of Protein-Protein Interactions through Allosteric Modulation of DynamicsStructures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.Structure and allosteric regulation of the X 2 integrin I domainEngineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studiesStructural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1A designed redox-controlled caspaseStructure ofStreptococcus agalactiaetip pilin GBS104: a model for GBS pili assembly and host interactionsRational design of intercellular adhesion molecule-1 (ICAM-1) variants for antagonizing integrin lymphocyte function-associated antigen-1-dependent adhesionStructural basis of integrin regulation and signalingInflamed leukocyte-mimetic nanoparticles for molecular imaging of inflammationA small molecule agonist of an integrin, alphaLbeta2.Dynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium.The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration.Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes.Forcing switch from short- to intermediate- and long-lived states of the alphaA domain generates LFA-1/ICAM-1 catch bondsExtracellular protein disulfide isomerase regulates ligand-binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammationIdentification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1.Combinatorial libraries against libraries for selecting neoepitope activation-specific antibodies.Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin alphaXbeta2Protein disulfide isomerase in thrombosis and vascular inflammationEngineering of single Ig superfamily domain of intercellular adhesion molecule 1 (ICAM-1) for native fold and function.FRET based quantification and screening technology platform for the interactions of leukocyte function-associated antigen-1 (LFA-1) with intercellular adhesion molecule-1 (ICAM-1).An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2.Temperature modulation of integrin-mediated cell adhesion.Anthrax toxin receptor 1/tumor endothelial marker 8: mutation of conserved inserted domain residues overrides cytosolic control of protective antigen bindingForce spectroscopy of the leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction.The state diagram for cell adhesion mediated by two receptors.I-domain of lymphocyte function-associated antigen-1 mediates rolling of polystyrene particles on ICAM-1 under flow.Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds.Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity.Two-dimensional kinetics regulation of alphaLbeta2-ICAM-1 interaction by conformational changes of the alphaL-inserted domainIsolation of αL I domain mutants mediating firm cell adhesion using a novel flow-based sorting method.Genetic analysis of integrin activation in T lymphocytes.Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity stateAL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes.
P2860
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P2860
Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Reversibly locking a protein f ...... d antagonist activity in vivo.
@ast
Reversibly locking a protein f ...... d antagonist activity in vivo.
@en
type
label
Reversibly locking a protein f ...... d antagonist activity in vivo.
@ast
Reversibly locking a protein f ...... d antagonist activity in vivo.
@en
prefLabel
Reversibly locking a protein f ...... d antagonist activity in vivo.
@ast
Reversibly locking a protein f ...... d antagonist activity in vivo.
@en
P2093
P2860
P356
P1476
Reversibly locking a protein f ...... d antagonist activity in vivo.
@en
P2093
A McCormack
M Shimaoka
R T Palframan
T A Springer
U H von Andrian
P2860
P304
P356
10.1073/PNAS.101130498
P407
P577
2001-05-15T00:00:00Z