Point mutations in a nucleoside transporter gene from Leishmania donovani confer drug resistance and alter substrate selectivity.
about
Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistancePhysiological consequences of drug resistance in Leishmania and their relevance for chemotherapyDrug resistance analysis by next generation sequencing in LeishmaniaPlasticity of the Leishmania genome leading to gene copy number variations and drug resistanceCharacterization of a Novel Endoplasmic Reticulum Protein Involved in Tubercidin Resistance in Leishmania majorEquilibrative nucleoside transporters-A review.Second-site suppression of a nonfunctional mutation within the Leishmania donovani inosine-guanosine transporter.Role of transmembrane domain 4 in ligand permeation by Crithidia fasciculata equilibrative nucleoside transporter 2 (CfNT2).Topology of a human equilibrative, nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporter (hENT1) implicated in the cellular uptake of adenosine and anti-cancer drugs.Genetic characterization of glucose transporter function in Leishmania mexicanaMolecular biology and regulation of nucleoside and nucleobase transporter proteins in eukaryotes and prokaryotes.Nutrient transport and pathogenesis in selected parasitic protozoa.Functional characterization of nucleoside transporter gene replacements in Leishmania donovaniNucleoside and nucleobase transporters in parasitic protozoa.Genetic dissection of pyrimidine biosynthesis and salvage in Leishmania donovani.TOR-induced resistance to toxic adenosine analogs in Leishmania brought about by the internalization and degradation of the adenosine permease.Purine and pyrimidine transport in pathogenic protozoa: from biology to therapy.Both sequence and context are important for flagellar targeting of a glucose transporter.Cysteine cross-linking defines the extracellular gate for the Leishmania donovani nucleoside transporter 1.1 (LdNT1.1).Two novel nucleobase/pentamidine transporters from Trypanosoma bruceiAn ab Initio structural model of a nucleoside permease predicts functionally important residues.Drug targets in Leishmania.Transport proteins of parasitic protists and their role in nutrient salvage.Assessing aquaglyceroporin gene status and expression profile in antimony-susceptible and -resistant clinical isolates of Leishmania donovani from India.Functional analysis of an inosine-guanosine transporter from Leishmania donovani. The role of conserved residues, aspartate 389 and arginine 393.Equilibrative nucleoside transporter family members from Leishmania donovani are electrogenic proton symporters.Functional expression and characterization of a purine nucleobase transporter gene from Leishmania major.A comparative evaluation of amphotericin B and sodium antimony gluconate, as first-line drugs in the treatment of Indian visceral leishmaniasis.Modulation in aquaglyceroporin AQP1 gene transcript levels in drug-resistant Leishmania.
P2860
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P2860
Point mutations in a nucleoside transporter gene from Leishmania donovani confer drug resistance and alter substrate selectivity.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Point mutations in a nucleosid ...... d alter substrate selectivity.
@ast
Point mutations in a nucleosid ...... d alter substrate selectivity.
@en
type
label
Point mutations in a nucleosid ...... d alter substrate selectivity.
@ast
Point mutations in a nucleosid ...... d alter substrate selectivity.
@en
prefLabel
Point mutations in a nucleosid ...... d alter substrate selectivity.
@ast
Point mutations in a nucleosid ...... d alter substrate selectivity.
@en
P2093
P2860
P356
P1476
Point mutations in a nucleosid ...... d alter substrate selectivity.
@en
P2093
G Vasudevan
S M Landfear
P2860
P304
P356
10.1073/PNAS.101537298
P407
P577
2001-05-15T00:00:00Z