4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1 - Wikidata - wikimedia - TriplyDB

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

http://www.wikidata.org/entity/Q35941218

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Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists Diacetyl increases sensory innervation and substance P production in rat trachea The search for novel analgesics: targets and mechanisms A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome Structure of the TRPA1 ion channel suggests regulatory mechanisms Unusual pungency from extra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system Chemokines and the pathophysiology of neuropathic pain Species-specific temperature sensitivity of TRPA1 Current understanding of the neuropathophysiology of pain in chronic pancreatitis How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy Role of oxidative stress & transient receptor potential in chronic obstructive pulmonary disease Deciphering Subtype-Selective Modulations in TRPA1 Biosensor Channels The TRPA1 channel in migraine mechanism and treatment The role of TRPA1 in visceral inflammation and pain TRPA1 channels in the vasculature Upregulation of the transient receptor potential ankyrin 1 ion channel in the inflamed human and mouse colon and its protective roles A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain Blocking TRPA1 in Respiratory Disorders: Does It Hold a Promise?Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation Nociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain Pathologies Transient receptor potential channels as therapeutic targets Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors The concept of neurogenic inflammation Acute cardiopulmonary toxicity of inhaled aldehydes: role of TRPA1 TRPA1 mediates mechanical sensitization in nociceptors during inflammation Methylglyoxal evokes pain by stimulating TRPA1 Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells TRPA1 contributes to cold hypersensitivity Warmth suppresses and desensitizes damage-sensing ion channel TRPA1 TRPA1 is a major oxidant sensor in murine airway sensory neurons General anesthetics activate a nociceptive ion channel to enhance pain and inflammation Activation of transient receptor potential ankyrin-1 (TRPA1) in lung cells by wood smoke particulate material Terpenes and lipids of the endocannabinoid and transient-receptor-potential-channel biosignaling systems Neurogenic Inflammation – The Peripheral Nervous System’s Role in Host Defense and Immunopathology Cellular and Molecular Mechanisms of Pain Role of TRPA1 in Acute Cardiopulmonary Toxicity of Inhaled Acrolein

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P2860

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

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2007 nî lūn-bûn

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Proceedings of the National Academy of Sciences of the United States of America

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4-Hydroxynonenal, an endogenou ...... of the irritant receptor TRPA1

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Allan I Basbaum

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Barbara Campi

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David Julius

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Diana M Bautista

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Graeme S Cottrell

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Jan Siemens

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Marcello Trevisani

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Nigel W Bunnett

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Noritaka Imamachi

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Pierangelo Geppetti

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P2860

Pungent products from garlic activate the sensory ion channel TRPA1

TRP channel activation by reversible covalent modification

Molecular mechanisms of nociception

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

Protein carbonylation, cellular dysfunction, and disease progression

Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1

TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction

TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

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13519-13524

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10.1073/PNAS.0705923104

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33

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104

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2007-08-07T00:00:00Z

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6155627

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17684094

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neuropathic pain

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1948902

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