Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea.
about
Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine.DNA repair and gene therapy: implications for translational uses.Overexpression of enzymes that repair endogenous damage to DNA.Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates.Methylation and colorectal cancer.Gene therapy for paediatric leukaemia.Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs.Foamy viral vector integration sites in SCID-repopulating cells after MGMTP140K-mediated in vivo selectionCotransduction with MGMT and Ubiquitous or Erythroid-Specific GFP Lentiviruses Allows Enrichment of Dual-Positive Hematopoietic Progenitor Cells In Vivo.Survival of the fittest: in vivo selection and stem cell gene therapyChemoselection of allogeneic HSC after murine neonatal transplantation without myeloablation or post-transplant immunosuppression.Influence of O6-benzylguanine on the anti-tumour activity and normal tissue toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and molecular combinations of 5-fluorouracil and 2-chloroethyl-1-nitrosourea in miceS-alkylthiolation of O6-methylguanine-DNA-methyltransferase (MGMT) to sensitize cancer cells to anticancer therapy.The therapeutic potential of O6-alkylguanine DNA alkyltransferase inhibitors.In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning.Long-term polyclonal and multilineage engraftment of methylguanine methyltransferase P140K gene-modified dog hematopoietic cells in primary and secondary recipientsImpaired growth and elevated fas receptor expression in PIGA(+) stem cells in primary paroxysmal nocturnal hemoglobinuriaLessons from genetically altered mesenchymal stem cells (MSCs): candidates for improved MSC-directed myocardial repair.A novel dual function retrovirus expressing multidrug resistance 1 and O6-alkylguanine-DNA-alkyltransferase for engineering resistance of haemopoietic progenitor cells to multiple chemotherapeutic agents.Programming of Cell Resistance to Genotoxic and Oxidative Stress.
P2860
Q30854723-22883A98-D79B-4958-B66C-85C934B7A53EQ33860360-4AE97835-09AF-4F20-8C85-F35CEE78E08CQ33888666-B26BF6C6-E5B0-4807-A2F9-DD0780EB2013Q33968014-53036A09-5300-4BDE-9E86-1B0785A60271Q34378429-D5C74B4B-CE93-47D5-B96D-6F0DC061D1F9Q34451905-8ACA9080-0D7E-445F-998F-1B691342D1BDQ34791132-FAD3E368-7DF4-4491-9EDB-B4F04AD4111DQ35812028-3546C39D-CA3F-49FF-A3FD-22F8FECE368EQ36128749-8EF58687-8603-411B-B35B-BCFB01E45910Q36306141-57F49686-5232-4086-8560-4AE17B7F0070Q36401055-CE98263D-C1AD-4B50-9972-DAC20D3D0B0CQ36619026-E8FF919D-712B-4DC5-A02F-E76BC6725700Q36734940-79290E34-D5FA-4B4A-857F-74A24E86AB8FQ36964700-DC28565A-AD2A-4DDC-BC4A-B8F82B24F7FFQ36990985-C0A6F124-0854-4573-B038-75CAE91C1694Q37201951-05C98144-C9C6-4F94-82C6-D4366530B417Q37267428-B1C88533-6903-475A-B5CA-606493C3B15BQ37955704-756EE52A-3F88-4F8D-BBA4-907656CF3A67Q40799213-14F0BD8F-91EC-4D19-AA88-A7EF3B75CB3DQ52730088-503CAC65-E55B-48AD-925F-C20DACB77C85
P2860
Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Retroviral transduction of a m ...... (2-chloroethyl)-1-nitrosourea.
@ast
Retroviral transduction of a m ...... (2-chloroethyl)-1-nitrosourea.
@en
type
label
Retroviral transduction of a m ...... (2-chloroethyl)-1-nitrosourea.
@ast
Retroviral transduction of a m ...... (2-chloroethyl)-1-nitrosourea.
@en
prefLabel
Retroviral transduction of a m ...... (2-chloroethyl)-1-nitrosourea.
@ast
Retroviral transduction of a m ...... (2-chloroethyl)-1-nitrosourea.
@en
P2093
P2860
P356
P1476
Retroviral transduction of a m ...... (2-chloroethyl)-1-nitrosourea.
@en
P2093
S L Gerson
W P Phillips
P2860
P304
14088-14093
P356
10.1073/PNAS.93.24.14088
P407
P577
1996-11-01T00:00:00Z