Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent
about
Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.Improving enzymes for cancer gene therapy.Overexpression of enzymes that repair endogenous damage to DNA.A rapid survival assay to measure drug-induced cytotoxicity and cell cycle effects.Gene transfer and the treatment of haematological malignancy.Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response.Knockdown of HPRT for selection of genetically modified human hematopoietic progenitor cellsRetroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea.Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression.Vector design for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells.Balancing repair and tolerance of DNA damage caused by alkylating agentsGene therapy approaches for stem cell protection.Transcription factors NF-YA regulate the induction of human OGG1 following DNA-alkylating agent methylmethane sulfonate (MMS) treatment.Co-expression of MGMT(P140K) and alpha-L-iduronidase in primary hepatocytes from mucopolysaccharidosis type I mice enables efficient selection with metabolic correction.Novel 19 F-MRS β-galactosidase reporter molecules incorporated nitrogen mustard analogues.Protection of hematopoietic cells from O(6)-alkylation damage by O(6)-methylguanine DNA methyltransferase gene transfer: studies with different O(6)-alkylating agents and retroviral backbones.A novel dual function retrovirus expressing multidrug resistance 1 and O6-alkylguanine-DNA-alkyltransferase for engineering resistance of haemopoietic progenitor cells to multiple chemotherapeutic agents.Hematopoietic progenitor cell transplantation in breast cancer: current status and future directions.DNA repair functions in heterologous cells.Retroviral gene therapy in hematopoietic diseases.Alkylation and Carbamylation Effects of Lomustine and Its Major Metabolites and MGMT Expression in Canine Cells.Synthesis and antitumor activity of novel nitrogen mustard-linked chalcones.Hematoprotection and enrichment of transduced cells in vivo after gene transfer of MGMT(P140K) into hematopoietic stem cells.A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase.Targeting autophagy enhances BO-1051-induced apoptosis in human malignant glioma cells.Programming of Cell Resistance to Genotoxic and Oxidative Stress.Synthesis and cytotoxicity evaluation of naphthalimide derived N-mustards.
P2860
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P2860
Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent
description
1996 nî lūn-bûn
@nan
1996 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Increasing DNA repair methyltr ...... motherapeutic alkylating agent
@ast
Increasing DNA repair methyltr ...... motherapeutic alkylating agent
@en
type
label
Increasing DNA repair methyltr ...... motherapeutic alkylating agent
@ast
Increasing DNA repair methyltr ...... motherapeutic alkylating agent
@en
prefLabel
Increasing DNA repair methyltr ...... motherapeutic alkylating agent
@ast
Increasing DNA repair methyltr ...... motherapeutic alkylating agent
@en
P2093
P2860
P356
P1476
Increasing DNA repair methyltr ...... motherapeutic alkylating agent
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.1.206
P407
P577
1996-01-01T00:00:00Z