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Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes † ‡Distal Heme Pocket Residues of B-type Dye-decolorizing Peroxidase: ARGININE BUT NOT ASPARTATE IS ESSENTIAL FOR PEROXIDASE ACTIVITYStructural analysis and insights into the glycon specificity of the rice GH1 Os7BGlu26 β-D-mannosidaseA Variable Active Site Residue Influences the Kinetics of Response Regulator Phosphorylation and Dephosphorylation.Remote exosites of the catalytic domain of matrix metalloproteinase-12 enhance elastin degradation.Synthetic biology.Designed divergent evolution of enzyme function.UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism.The TonB dimeric crystal structures do not exist in vivo.New insight into long-range nonadditivity within protein double-mutant cyclesIdentification of amino acid residues contributing to the mechanism of cooperativity in Escherichia coli D-3-phosphoglycerate dehydrogenase.Two variable active site residues modulate response regulator phosphoryl group stabilityHigh tolerance to simultaneous active-site mutations in TEM-1 beta-lactamase: Distinct mutational paths provide more generalized beta-lactam recognitionDirected evolution of a ring-cleaving dioxygenase for polychlorinated biphenyl degradation.Impact of individual mutations on increased fitness in adaptively evolved strains of Escherichia coliCharacterization of the interdependency between residues that bind the substrate in a beta-glycosidase.The energetic network of hotspot residues between Cdc25B phosphatase and its protein substrate.Electrostatic stabilization in a pre-organized polar active site: the catalytic role of Lys-80 in Candida tenuis xylose reductase (AKR2B5) probed by site-directed mutagenesis and functional complementation studies.Contribution of amino acid region 334-335 from factor Va heavy chain to the catalytic efficiency of prothrombinase.The oxyanion hole of Pseudomonas fluorescens mannitol 2-dehydrogenase: a novel structural motif for electrostatic stabilization in alcohol dehydrogenase active sites.Functional characterization of a Plagiochasma appendiculatum flavone synthase I showing flavanone 2-hydroxylase activity.Engineering ATPase activity in the isolated ABC cassette of human TAP1.Incorporation of factor Va into prothrombinase is required for coordinated cleavage of prothrombin by factor Xa.Inositol Monophosphatase: A Bifunctional Enzyme in
P2860
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P2860
description
2004 nî lūn-bûn
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2004年の論文
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2004年論文
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2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
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2004年论文
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2004年论文
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name
Inverse thinking about double mutants of enzymes.
@ast
Inverse thinking about double mutants of enzymes.
@en
type
label
Inverse thinking about double mutants of enzymes.
@ast
Inverse thinking about double mutants of enzymes.
@en
prefLabel
Inverse thinking about double mutants of enzymes.
@ast
Inverse thinking about double mutants of enzymes.
@en
P356
P1433
P1476
Inverse thinking about double mutants of enzymes.
@en
P2093
Albert S Mildvan
P304
14517-14520
P356
10.1021/BI048052E
P407
P577
2004-11-01T00:00:00Z