Fialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration.
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Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation PlansAntiviral L-nucleosides specific for hepatitis B virus infectionTGN1412: From Discovery to DisasterMitochondrial dna depletion, oxidative stress, and mutation: mechanisms of dysfunction from nucleoside reverse transcriptase inhibitors.Anti-HBV specific beta-L-2'-deoxynucleosides.Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts.Animal models of idiosyncratic drug-induced liver injury--current status.Differential effects of the incorporation of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) on the binding of the transcription factors, AP-1 and TFIID, to their cognate target DNA sequences.The Promise of New Technologies to Reduce, Refine, or Replace Animal Use while Reducing Risks of Drug Induced Liver Injury in Pharmaceutical Development.Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine.Pharmacologic considerations for antiviral drug development.RNA Therapeutics in Oncology: Advances, Challenges, and Future Directions.An evaluation of the toxicities of 2'-fluorouridine and 2'-fluorocytidine-HCl in F344 rats and woodchucks (Marmota monax).
P2860
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P2860
Fialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Fialuridine accumulates in DNA ...... long-term oral administration.
@ast
Fialuridine accumulates in DNA ...... long-term oral administration.
@en
type
label
Fialuridine accumulates in DNA ...... long-term oral administration.
@ast
Fialuridine accumulates in DNA ...... long-term oral administration.
@en
prefLabel
Fialuridine accumulates in DNA ...... long-term oral administration.
@ast
Fialuridine accumulates in DNA ...... long-term oral administration.
@en
P2093
P2860
P356
P1476
Fialuridine accumulates in DNA ...... long-term oral administration.
@en
P2093
Bowsher RR
Engelhardt JA
Richardson FC
P2860
P304
12003-12007
P356
10.1073/PNAS.91.25.12003
P407
P577
1994-12-01T00:00:00Z